Evidence map›Paper›PMID 41228412›Full record

ArticleNutrients2025

Effects of Dietary Vitamin D Levels on Markers Related to Amyloidogenesis and Neuroinflammation in db/db Mice.

Jisu Kim, Dain Wi, Sung Nim Han, Chan Yoon Park

Abstract read
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In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jisu KimDepartment of Food and Nutrition, The University of Suwon, Hwaseong 18323, Republic of Korea.
Dain WiDepartment of Food and Nutrition, The University of Suwon, Hwaseong 18323, Republic of Korea.ORCID 0009-0005-8182-1445
Sung Nim HanDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Republic of Korea.ORCID 0000-0003-0647-2992
Chan Yoon ParkDepartment of Food and Nutrition, The University of Suwon, Hwaseong 18323, Republic of Korea.ORCID 0000-0002-8597-7210

Funding

National Research Foundation of Korea NRF-RS-2024-00353119National Research Foundation of Korea NRF-RS-2024-00455010
6 · The paper itself

Abstract

BACKGROUND/

objectivesLow vitamin D levels are associated with an elevated risk of Alzheimer's disease (AD). Given the rising prevalence of diabetes and its association with AD, this study investigated whether vitamin D modulates amyloidogenesis and inflammation in the brains of diabetic mice.

methodsFive-week-old male C57BLKS/J-

resultsHigh dietary vitamin D levels attenuated neuronal necrosis in db/db mice. Hippocampal

conclusionsThese findings suggest that vitamin D may exert neuroprotective effects on the hippocampus and PFC in diabetic mice by mitigating neuronal damage and suppressing amyloidogenic and inflammatory gene expression.

Indexed as

Alzheimer DiseaseDiabetes Mellitus, ExperimentalDietNeuroinflammatory DiseasesVitamin DAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsAspartic Acid EndopeptidasesBiomarkersHippocampusMaleMiceMice, Inbred C57BLNeuronsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBace1 protein, mouseBiomarkersVitamin DAlzheimer’s diseaseamyloidogenesisneuroinflammationtype 2 diabetesvitamin D

Identifiers

PMID41228412
PMCPMC12608884

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.