Evidence map›Paper›PMID 41228497›Full record

ReviewNutrients2025

Restoring Balance: The Role of Omega-3 Polyunsaturated Fatty Acids on the Gut-Brain Axis and Other Interconnected Biological Pathways to Improve Depression.

Floriana De Cillis, Veronica Begni, Patrizia Genini, Daniele Leo, Marco Andrea Riva, Annamaria Cattaneo

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Floriana De CillisDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-6869-5337
Veronica BegniBiological Psychiatry Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.ORCID 0000-0003-2244-1782
Patrizia GeniniDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0009-0005-1238-5440
Daniele LeoBiological Psychiatry Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Marco Andrea RivaDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-1699-5060
Annamaria CattaneoDepartment of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-9963-848X

Funding

EarlyCause Project 848158Ministero della Salute Ricerca CorrenteMinistero dell'università e della ricerca PON "Ricerca e Innovazione" PerMedNet project ARS01_01226Ministero dell'università e della ricerca PRIN 2017AY8BP4Ministero dell'università e della ricerca PRIN 202277LAA7
6 · The paper itself

Abstract

Major depressive disorder (MDD) is a complex, multifactorial condition involving dysregulation across immune, neural, and metabolic systems. Omega-3 polyunsaturated fatty acids (

Indexed as

Antidepressive AgentsBrainBrain-Gut AxisFatty Acids, Omega-3Gastrointestinal MicrobiomeMajor Depressive DisorderAnimalsEicosapentaenoic AcidHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemAntidepressive AgentsEicosapentaenoic AcidFatty Acids, Omega-3gut–brain axishypothalamic–pituitary–adrenal axisinflammationmajor depressive disorderneuroplasticityomega-3 polyunsaturated fatty acidsoxidative stress

Identifiers

PMID41228497
PMCPMC12608965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.