Evidence mapPaperPMID 41228523Full record

ReviewNutrients2025

The Multi-Dimensional Action Map of Resveratrol Against Alzheimer's Disease: Mechanism Integration and Treatment Strategy Optimization.

Yichen Liu, Yadan Dong, Zhen Cao, Yixuan Ji, Xiaoxin Cheng, Xu Zheng

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yichen LiuCollege of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Yadan DongCollege of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Zhen CaoCollege of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Yixuan JiCollege of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Xiaoxin ChengCollege of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Xu ZhengCollege of Basic Medical Science, Dalian Medical University, Dalian 116044, China.

Funding

the Youth Talent Cultivation Fund Project of Dalian Medical University.
6 · The paper itself

Abstract

Alzheimer's disease (AD) represents a prevalent neurodegenerative disorder marked by a gradual decline in cognitive and behavioral functions. Despite advancements in elucidating several potential mechanisms underlying the pathogenesis of AD, there remains a limitation in effective supplements or medications for its intervention. Resveratrol, a natural antioxidant, has emerged as a significant player in the treatment of AD. This article reviews the role of resveratrol in four key aspects: amyloid plaque deposition and neurofibrillary tangles, inflammatory response and oxidative stress, energy metabolism and mitochondrial homeostasis, and neuroprotection and regeneration. Furthermore, we also explore treatment strategies to enhance the therapeutic effect of resveratrol.

Indexed as

Alzheimer DiseaseAntioxidantsNeuroprotective AgentsResveratrolAnimalsEnergy MetabolismHumansMitochondriaNeurofibrillary TanglesOxidative StressPlaque, AmyloidAntioxidantsNeuroprotective AgentsResveratrolAlzheimer’s diseaseanti-inflammatorymitochondrial homeostasisneuroprotectionresveratrol

Identifiers

PMID41228523
PMCPMC12608997

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.