Evidence map›Paper›PMID 41228597›Full record

ReviewPolymers2025

Chitosan (Nano)formulations as Therapeutic Tools for Neurodegenerative Diseases: A Comprehensive Review.

Adriana C C Gomes, Adelaide Almeida, Carmen S R Freire, Bárbara Leite Ferreira

Abstract readReview
In one paragraph

Review in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adriana C C GomesCICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-6144-7859
Adelaide AlmeidaCESAM-Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-8422-8664
Carmen S R FreireCICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-6320-4663
Bárbara Leite FerreiraCICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-0221-3160

Funding

FCT/MCTES (PIDDAC) LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020)FCT/MCTES (PIDDAC) UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020)FCT/MCTES (PIDDAC) UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020)FCT/MCTES (PIDDAC) (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020)Fundação para a Ciência e Tecnologia 2022.10449.BD (https://doi.org/10.54499/2022.10449.BD)Fundação para a Ciência e Tecnologia DOI 10.54499/ND/00464/2017/CP1459/CT0033National funds (OE), through FCT DOI: 10.54499/DL57/2016/CP1482/CT0019
6 · The paper itself

Abstract

According to the World Health Organization, Alzheimer's disease and other forms of dementia were the seventh leading cause of death in 2021. The prevalence of these disorders is predictable to increase with life expectancy, and their control is hampered by several factors, including late diagnosis due to the lack of specific biomarkers and the absence of disease-modifying treatments, as currently available therapies can only lighten some of the symptoms. Nanotechnology could be the key to overcoming some of the limitations associated with neurodegenerative diseases, as nanomaterials have excellent properties compared to their bulk counterparts and can be used as drug delivery systems, diagnostic tools and platforms for tissue regeneration. Chitosan is a biopolymer with numerous properties that impart it with great potential for biomedical applications, in particular its ability to cross the blood-brain barrier and its versatility in nanoscale design. In this context, the aim of this review is to provide an in-depth analysis of the latest developments and future opportunities for chitosan (nano)formulations for the treatment and management of neurodegenerative diseases.

Indexed as

chitosandrug deliverynanoformulationsneurodegenerative diseasestherapeutic tools

Identifiers

PMID41228597
PMCPMC12609354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.