ArticleSensors (Basel, Switzerland)2025
Precise Control of Micropipette Flow Rate for Fluorescence Imaging in In Vivo Micromanipulation.
Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Precise regulation of micropipette outlet flow is critical for fluorescence imaging in vivo micromanipulations. In such procedures, a micropipette with a micro-sized opening is driven by gas pressure to deliver internal solution into the in vivo environment. The outlet flow rate needs to be precisely regulated to ensure a uniform and stable fluorescence distribution. However, conventional manual pressure injection methods face inherent limitations, including insufficient precision and poor reproducibility. Existing commercial microinjection systems lack a quantitative relationship between pressure and flow rate. And existing calibration methods in the field of microfluidics suffer from a limited flow-rate measurement resolution, constraining the establishment of a precise pressure-flow quantitative relationship. To address these challenges, we developed a closed-loop pressure regulation system with 1 Pa-level control resolution and established a quantitative calibration of the pressure-flow relationship using a droplet-based method. The calibration revealed a linear relationship with a mean pressure-flow gain of 4.846 × 10-17m3·s-1·Pa-1 (R
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