Evidence map›Paper›PMID 41229263›Full record

ArticleCardiorenal medicine2025

Associations between Arterial Stiffness, Electrolytes, and Hormones: Insights from the LURIC Study on Cardiovascular Health.

Angela P Moissl-Blanke, Graciela E Delgado, Goekhan Yücel, Clara Daschner, Marcus E Kleber, Bernhard K Krämer, Winfried März, Babak Yazdani

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In one paragraph

Article in Cardiorenal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angela P Moissl-BlankeDepartment of Medicine I (Cardiology, Angiology, Hemostaseology, Intensive Care), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Graciela E DelgadoLURIC Study GmbH, Aystetten, Germany.
Goekhan YücelDepartment of Medicine I (Cardiology, Angiology, Hemostaseology, Intensive Care), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Clara DaschnerMedical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
Marcus E KleberDepartment of Medicine I (Cardiology, Angiology, Hemostaseology, Intensive Care), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Bernhard K KrämerMedical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
Winfried MärzSynlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany.
Babak YazdaniFifth Department of Medicine, University Medical Center Mannheim, Faculty of Medicine of the University of Heidelberg, Mannheim, Germany, babak.yazdani@umm.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulse pressure (PP), the difference between systolic (SBP) and diastolic blood pressure (DBP), is an essential marker of cardiovascular (CV) health and arterial stiffness. Elevated PP is linked to a higher risk of CV events, a major cause of global mortality. This study examines its association with key electrolytes - sodium, potassium, calcium, magnesium, phosphate, and vitamin D - in blood-pressure regulation and vascular function.

methodsWe analysed data from 3,316 LURIC participants who underwent coronary angiography and had a median follow-up of 9.9 years. Fasting blood samples were collected at baseline. Associations between PP and electrolyte levels were assessed using Spearman correlation. Logistic regression models were used to calculate odds ratios (ORs) per standard deviation (SD) of PP and electrolyte concentrations for four clinical outcomes: all-cause mortality, CV mortality, reduced estimate the glomerular filtration rate (eGFR), and type 2 diabetes mellitus.

resultsThe cohort's average age was 62.7 years, with 70% of participants being male. Higher PP was significantly associated with older age, increased body mass index, and the prevalence of coronary artery disease (CAD), carotid stenosis, and peripheral arterial disease. Potassium, phosphate, renin, 25-OH, and 1,25-OH vitamin D concentrations decreased significantly as PP increased, while sodium remained unchanged. Sodium-potassium ratio and aldosterone-renin ratio increased with higher PP. Women had a higher risk of CV mortality per SD of PP (OR 1.57; 95% confidence interval [CI]: 1.33-1.86), while men showed a greater risk of reduced eGFR (OR 1.59; 95% CI: 1.40-1.80).

conclusionSpecific electrolyte imbalances are closely linked to increased PP and arterial stiffness. Our findings highlight sex-specific CV risk and support further research into nutrient-based and hormonal interventions targeting PP modulation.

Indexed as

Blood PressureCardiovascular DiseasesElectrolytesHormonesVascular StiffnessAgedCoronary AngiographyFemaleGlomerular Filtration RateHumansMaleMiddle AgedRisk FactorsElectrolytesHormonesBlood pressureCardiovascular riskChronic kidney diseaseLudwigshafen risk and cardiovascular health studyNutrientsPulse pressureSex factorsSodium-potassium ratioVascular stiffness

Identifiers

PMID41229263
PMCPMC12705091

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.