ArticleFrontiers in public health2025
Prospective longitudinal study of dynamic depressive symptom trajectories and diabetes onset risk in older adults: a 10-year follow-up of the HRS and ELSA cohorts.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The study aimed to examine the longitudinal relationship between depressive symptom trajectories and diabetes onset risk in older adults, with particular attention to sex-specific variations. Methods: Data were drawn from the Health and Retirement Study (HRS) and the English Longitudinal Study of Ageing (ELSA). Depressive symptoms were measured using CESD-8, and five trajectories were identified: consistently low, decreasing, fluctuating, increasing, and consistently high. Symptoms were further divided into somatic and cognitive-affective domains. Cox proportional hazards models were applied to estimate diabetes onset risk, controlling for demographics, health behaviors, and comorbidities. Analyses stratified by sex were conducted to assess differential effects. Results: A total of 8,741 participants aged 50 years and older from both cohorts were included. During 10 years of follow-up, increasing (HR = 1.746, 95% CI: 1.195-2.551, Conclusion: Persistent or worsening depressive symptoms serve as significant predictors of diabetes onset risk, particularly among women. Both cognitive-affective and somatic domains contribute independently, emphasizing the importance of dynamic mental health surveillance in diabetes prevention.
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