Evidence map›Paper›PMID 41229543›Full record

ArticleFrontiers in nutrition2025

Low level of serum total cholesterol predicts mortality in early-stage multiple system atrophy: a prospective-cohort study.

Jingxuan Huang, Lingyu Zhang, Qirui Jiang, Shichan Wang, Yi Xiao, Ningning Che, Junyu Lin, Bi Zhao, Yangfan Cheng, Chunyu Li and 1 more

Abstract read
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In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jingxuan HuangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Lingyu ZhangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Qirui JiangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Shichan WangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Yi XiaoLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Ningning CheLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Junyu LinLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Bi ZhaoLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Yangfan ChengLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Chunyu LiLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
Huifang ShangLaboratory of Neurodegenerative Disorders, Department of Neurology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Serum total cholesterol (TC) is associated with the risk of multiple system atrophy (MSA). However, the potential impact of the serum TC levels on the mortality of patients with MSA remains to be elucidated. The study aims to clarify the association between baseline level of serum TC and survival of patients with early MSA. Methods: A total of 364 patients with MSA were recruited and assessed at baseline and follow-up. Patients with MSA were stratified into three groups based on the serum TC tertiles. The role of serum TC on survival was analyzed using Kaplan-Meier survival analysis and Cox regression models. Restricted Cubic Spline regression was employed to investigate the non-linear relationship between serum TC levels and survival. Results: During a median follow-up period of 4.75 years, the survival duration of patients with MSA was shorter in the lowest serum TC group compared to the other two groups (Log-rank Conclusion: Serum TC level at baseline negatively correlated with survival of patients with MSA. Serum TC emerges as a significant predictor of mortality in patients with early-stage MSA.

Indexed as

MSApredictorprospective observational cohortserum total cholesterolsurvival

Identifiers

PMID41229543
PMCPMC12602236

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.