ReviewFrontiers in microbiology2025
The gut-lung axis in asthma: microbiota-driven mechanisms and therapeutic perspectives.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of probiotics, prebiotics, and synbiotics on lung function and symptoms in adults with bronchial asthma: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Efficacy and safety of probiotics in the treatment of pediatric asthma: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Probiotic modulation of gut microbiota with Bifidobacterium animalis subsp. lactis XLTG11 and Lactobacillus plantarum CCFM8661 mitigates recurrent respiratory infections in children: a randomised-controlled trial.European journal of nutrition · 2026Trial
- Axial Connectivity of the Lung Microbiome: A Review of Interorgan Crosstalk.Comprehensive physiology · 2026Review
- The avian respiratory microenvironment-immune nexus: A three-dimensional regulation model from local homeostasis to systemic defense.Poultry science · 2026Article
- The Gut-Lung Microbiome Axis in Alveolar Stem Cell Regeneration and Lung Repair.Microorganisms · 2026Review
- Gut and respiratory microbiomes in asthma and allergic diseases: a narrative review of mechanistic insights, gut-lung axis interactions and therapeutic opportunities.Translational pediatrics · 2026Review
- Baicalein mitigates epithelial barrier impairment and microbiota dysbiosis in allergic asthmatic mice via the gut‑lung axis.Chinese medicine · 2026Article
- The Gut-Lung Axis in Allergic Asthma: A Narrative Review of Microbial Dysbiosis, Immune Regulation, and Nutritional Modulation.Nutrients · 2026Review
- Mechanisms by which complex carbohydrates influence immune imbalance in COPD via the gut-lung axis: from colonic fermentation to pulmonary immune responses.Frontiers in nutrition · 2026Review
- Epigenetics in asthma: implications for treatable traits.Frontiers in allergy · 2026Review
- Evaluating the Impact of Prophylactic Administration of Ivermectin on the Fecal Microbiome of Healthy C57BL/6J Mice (Mus musculus).Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a multifactorial inflammatory airway disease shaped by complex interactions among host genetics, environmental exposures, and the microbiota. The human body hosts a highly diverse microbial ecosystem, comprising more than 10,000 species that profoundly influence host physiology through the regulation of nutrient metabolism and immune homeostasis. Disruption of this balance, or dysbiosis, contributes to the onset and progression of immune-mediated diseases, including asthma. Asthma is a multifactorial disorder driven by the complex interaction of genetic susceptibility and environmental exposures, and its heterogeneous phenotypes and severity are increasingly associated with alterations in the microbiota. In particular, the gut-lung axis represents a critical bidirectional pathway through which microbial communities and their metabolites in the gut and airways shape immune responses and respiratory health. This review summarizes current evidence on microbiota-driven mechanisms underlying asthma pathogenesis, highlights the role of the gut-lung axis in immune regulation, and discusses emerging microbiota-targeted therapeutic strategies, emphasizing their potential for clinical translation in asthma treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.