Real-world oncologic outcomes of thoracoscopic and open tracheal cancer resection.

Background: Minimally invasive video-assisted thoracoscopic surgery (VATS) for tracheal cancer is gaining popularity. However, data are limited to single-center reports and short-term outcomes. In this context, we aim to compare short and long-term oncologic outcomes of VATS versus open tracheal cancer resection at the national level. Methods: We used a national dataset to isolate primary tracheal cancers diagnosed between 2010-2021. Patients were stratified by operative approach into open and VATS resection groups. Cox analysis was used to estimate proportional effects of covariates in unmatched cohorts. We then used propensity score matching to minimize confounding bias from covariates. Kaplan-Meier survival analyses were used to estimate 5-year survival. Results: Of 331 patients undergoing tracheal cancer resection, 147 (44.4%) were started VATS with 5 (3.4%) converting to open. Patients undergoing VATS tracheal resection were similar in age (62.4±14.5 Conclusions: In this national observational study, we found that the short-term benefits of thoracoscopic tracheal resection come at the expense of increased positive margins and worse survival. Adoption of this approach for tracheal cancer should be met with caution.