ArticleJournal of thoracic disease2025
Differences in pulmonary nodular consolidation features among drug-sensitive pulmonary tuberculosis and multidrug/extensively-resistant pulmonary tuberculosis: a multi-national multi-center study.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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34 authors.
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Abstract
Background: Pulmonary nodular consolidation (PN) may represent an imaging sign potentially useful in differentiating multidrug-resistant (MDR) pulmonary tuberculosis (PTB) from drug-sensitive (DS) tuberculosis (TB) on chest computed tomography (CT). This study aims to confirm the difference in PN features between DS and MDR patients. Methods: Eastern European (Belarus, Moldova, Romania, Azerbaijan, and Georgia) patient data were obtained from the NIAID TB (National Institute of Allergy & Infectious Diseases Tuberculosis) Portals Program registered before January 2019. Chinese patients were obtained from Shenzhen, China, treated between April 2017 and February 2019. There were in total 244 DS cases (222 new patients and 22 previously treated patients), 344 MDR cases (188 new patients and 156 previously treated patients), 155 extensively drug-resistant (XDR) TB cases (36 new patients and 119 previously treated patients). The first CT scan's images were used. A PN was defined as rounded or oval with a relatively clear boundary measuring between 6 and 30 mm in diameter. Calcified lesions in the lungs, as a sign of chronicity, were also recorded. Results: In new patients, there was no difference in lung lesion calcification prevalence among DS (16.1%) and MDR (15.0%). In previously treated patients, lung calcification prevalence was 38.5% for DS, 48.3% for MDR, and 52.8% for XDR. For new patients, the PN prevalence was higher for MDR/XDR cases than for DS cases (around 70% Conclusions: MDR/XDR patients exhibit significantly higher PN prevalence and more extensive pulmonary involvement compared to DS patients and which is not totally determined by disease history length, suggesting that PN characteristics could serve as imaging biomarkers for drug resistance assessment.
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