Evidence map›Paper›PMID 41229880›Full record

ArticleOpen forum infectious diseases2025

Female Sex is Protective Against MASLD With Clinically Significant Fibrosis in a Large Cross-sectional Cohort of Persons With HIV.

Kara Wegermann, Ayako Suzuki, Elisa Sarmiento, LaKeisha Boyd, Yang Li, Laura A Wilson, Audrey Lloyd, Paula Debroy, Jennifer C Price, Tinsay Woreta and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kara WegermannDivision of Gastroenterology, Department of Medicine, Duke University Health System, Durham, NC, USA.ORCID https://orcid.org/0000-0002-1024-9040
Ayako SuzukiDivision of Gastroenterology, Department of Medicine, Duke University Health System and Durham Veterans Affairs Medical Center, Durham, NC, USA.
Elisa SarmientoDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine and Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0001-7283-9938
LaKeisha BoydDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine and Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0003-3549-2124
Yang LiDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine and Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0001-7024-7103
Laura A WilsonJohns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.
Audrey LloydDivision of Infectious Diseases, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.ORCID https://orcid.org/0000-0001-5906-527X
Paula DebroyDivision of Infectious Diseases, Department of Internal Medicine, UTHealth Houston, Houston, TX, USA.
Jennifer C PriceDivision of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Tinsay WoretaJohns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-7292-4518
Holly CrandallDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.
Richard K SterlingDivision of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Rohit LoombaDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Naga ChalasaniDivision of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA.
Jordan E LakeDivision of Infectious Diseases, Department of Internal Medicine, UTHealth Houston, Houston, TX, USA.ORCID https://orcid.org/0000-0002-0640-5514

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Men are at higher risk for metabolic dysfunction-associated steatotic liver disease (MASLD) with clinically significant fibrosis (CSF) than premenopausal women, but data are lacking in persons with HIV (PWH). The aim of this study was to discover prevalence and severity of MASLD in PWH by sex assigned at birth and menopausal status. Methods: We examined participants from the prospective, cross-sectional HIV NASH CRN who had suppressed HIV-1 RNA, self-reported sex assigned at birth and menopause status, and underwent transient elastography (TE). The primary outcome was MASLD (controlled attenuation parameter [CAP] ≥ 263 dB/m, ≥1 cardiometabolic risk factor, Alcohol Use Disorders Identification Test score <8) with CSF (MASLD-CSF, TE Liver Stiffness Measurement ≥ 8 kPa). Results: Nine hundred and sixty-four PWH were included: 709 men (73.5%) and 255 women (26.5%) with similar median ages (55.1 and 56.6 years, Conclusions: Female sex was protective against MASLD-CSF in PWH. Men with diabetes, hyperlipidemia, and high WC would be candidates for MASLD screening. Further studies of PWH with women, especially more young women, are needed.

Indexed as

estrogenhepatic fibrosismenopausetestosteronewomen’s health

Identifiers

PMID41229880
PMCPMC12604012

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.