ArticleInternational journal of women's health2025
Causal Relationships Among Lifestyle, Lipidome, and Polycystic Ovary Syndrome: A Mendelian Randomization Study.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lifestyle interventions often influence lipid levels in patients with polycystic ovary syndrome (PCOS), thereby modulating disease progression. However, whether lipid levels play a mediating role remains unclear. Objective: To investigate causal associations between lifestyle, lipidome, and PCOS, as well as mediating role of lipidome. Methods: This study employed a bidirectional two-sample Mendelian randomization (MR) analysis, with lifestyle and lipidome as exposures and PCOS as outcome. A two-step MR approach was used to assess mediating role of lipidome. Inverse-variance weighted (IVW) method was primarily applied, and sensitivity analyses were conducted to test robustness of results. Results: Overall physical activity time (OR = 0.590, 95% CI: 0.394-0.882, Conclusion: This study revealed causal associations between overall physical activity time, leisure screen time, and PCOS, and identified mediating role of TAG (50:1) levels. These findings provide scientific insights for lifestyle management in PCOS patients.
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