ReviewTranslational andrology and urology2025
Antidiabetic agents and male fertility: unraveling the impact of glucose-lowering therapies on sperm quality in diabetic males-a narrative review.
Review in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Diabetes mellitus imposes a substantial burden on male fertility, adversely affecting sperm quality through structural damage in the reproductive tract, endocrine disruption, and dysregulation of cellular metabolism. While glucose-lowering agents help achieve glycemic control, they may also ameliorate diabetes-induced impairment of sperm quality. However, these drugs exert heterogeneous effects on male reproduction via divergent mechanisms, with outcomes often varying between Methods: A comprehensive search of the PubMed and Embase databases was conducted, covering the period from their inception to 2025. Key Content and Findings: Insulin enhances sperm DNA integrity via Hsp70-2/TP-1/TP-2 upregulation and acts as a cryoprotectant. Metformin activates AMPK-mediated autophagy and synergizes with zinc to preserve fertility. SGLT-2 inhibitors suppress testicular apoptosis via Nrf2/HO-1 antioxidant pathways. Critically, sulfonylureas improve Conclusions: Current evidence supports the potential of certain antihyperglycemic agents in mitigating diabetes-related male infertility, though drug-specific and context-dependent effects must be considered. Further phenotype-targeted studies are needed to optimize clinical treatment strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.