ArticlePatient preference and adherence2025
Implementation and Evaluation of a Real-Time Prescription Alert System to Optimize Antiretroviral Therapy and Medication Adherence in People Living with HIV. SANPAT PROJECT.
Article in Patient preference and adherence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Multidimensional Framework for Pharmaceutical Care to Enhance Medication Adherence and Patient Engagement: The CMO-MAPEX Model.Patient preference and adherence · 2026Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: To evaluate the clinical and implementation impact of "Alert System for New Prescriptions and Therapeutic Adherence Monitoring" (SANPAT), a real-time prescription alert system embedded in a structured pharmaceutical care model, aimed at optimizing antiretroviral therapy (ART) and improving medication adherence in people living with HIV (PLWH). Patients and Methods: A quasi-experimental, before-and-after study was conducted in a hospital outpatient pharmaceutical care unit in Andalusia, Spain. Patients aged ≥50 years receiving ART were included if they had polypharmacy (≥6 concurrent medications) or demonstrated poor adherence. The pre-intervention period (Feb 2023-Jan 2024) relied on standard care without alerts. The post-intervention period (Feb 2024-Jan 2025) incorporated SANPAT, enabling pharmacists to receive real-time alerts for new prescriptions and adherence risks. Pharmaceutical interventions were classified using a validated Capacity-Motivation-Opportunity (CMO)-based taxonomy, and implementation was evaluated using the Reach, Effectiveness, Adoption, Implementation y Maintenance (RE-AIM) framework. Results: A total of 153 patients were included (84 pre- and 69 post-intervention). The number of pharmacist interventions increased markedly post-intervention (from 84 to 877 events), especially in adherence support (0.0% to 47.2%) (p<0.001) and medication error prevention (0.0% to 34.7%) (p<0.001). The frequency of polypharmacy and major polypharmacy increased, while immunovirological risk markers improved (CD4 cell count<200 cells/μL decreased from 15.0% to 4.3%; detectable viral load from 20.3% to 3.6%) (p<0.001). The RE-AIM evaluation demonstrated broad reach, high adoption, improved implementation metrics, and early signs of long-term sustainability. Conclusion: SANPAT significantly enhanced the timely identification and resolution of pharmacotherapeutic risks in PLWH, supporting personalized interventions and optimizing ART management. Its integration within existing electronic prescribing populations.platforms and structured care models represents a scalable strategy to improve medication safety in aging and complex patients.
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