ArticleClinical interventions in aging2025
Prognostic Value of Glucose-to-Potassium Ratio in Acute Ischemic Stroke Patients Undergoing Thrombolysis and Its Interaction with Inflammation.
Article in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The glucose-to-potassium ratio (GPR) has been proven to be an early predictor of central nervous system injury. Meanwhile, it has a potential interaction with the inflammatory response. Therefore, we aimed to comprehensively analyze the prognostic value of GPR for thrombolytic acute ischemic stroke (AIS) patients and its synergistic effect with the neutrophil-to-lymphocyte ratio (NLR). Methods: AIS patients treated with thrombolysis were retrospectively enrolled at the First Affiliated Hospital of Wenzhou Medical University between February 1st, 2018, and December 31st, 2021. Cox and Logistic regression were used for evaluating the predictive value of GPR for the prognosis of AIS patients. Patients were grouped according to GPR and NLR levels to study the synergistic effect of GPR and NLR. Results: In a cohort of 606 patients, after adjusting for significant confounding factors in a multivariate regression analysis, GPR was able to independently predict adverse outcomes such as 6-mRS [odds ratio (OR) = 1.743, 95% confidence interval (CI): 1.271-2.389, Conclusion: GPR independently predicts adverse outcomes in AIS patients, and its addition to the prediction model improves predictive accuracy. There's a synergistic effect between GPR and NLR on adverse outcomes.
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