ArticleAngewandte Chemie (International ed. in English)2026
Enhanced Selectivity of Chalcogen Bonding over Halogen Bonding Catalyzed C-glycosylation Through Differentiated Intermediate Activation.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross-Disciplinary Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chalcogen···π Bonding Catalysis: Concept, Reaction Development and Emerging Opportunities.Chemistry, an Asian journal · 2026Review
- Ligand-enabled next-generation glycosyl Stille cross-coupling for the stereospecific synthesis of sterically hindered aryl C-glycosides.Nature communications · 2026Article
- Enhanced Selectivity of Chalcogen Bonding over Halogen Bonding Catalyzed C-glycosylation Through Differentiated Intermediate Activation.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
2 authors.
Funding
Abstract
σ-hole-based noncovalent interactions are gaining intense attention as robust tools in stereoselective carbohydrate synthesis. However, the mechanistic understanding behind the differing performance between chalcogen bonding (ChB) catalysis versus halogen bonding (XB) catalysis in chemical glycosylations still remains unresolved. Herein, we disclose a remarkable instance whereby phosphonochalcogenide (PCH) catalysis displays pronounced selectivity and reactivity elevation in aryl-C-glycosylations compared to XB catalysis. Mechanistic studies revealed that the enhanced stereocontrol can be attributed to the differentiated downstream activation of a key bicyclic intermediate. Hammett analysis supported that ChB catalysis shifted the C-glycosylation toward the S
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.