ArticleIrish journal of medical science2026
The role of early postoperative lactate dynamics in predicting acute kidney injury and mortality after HIPEC.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation.Renal failure · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is an established treatment for selected peritoneal surface malignancies. However, postoperative hemodynamic fluctuations, fluid shifts, and nephrotoxic chemotherapeutic agents may increase the risk of acute kidney injury (AKI). Early postoperative lactate levels and lactate clearance are markers of tissue perfusion and metabolic recovery, but their prognostic role after HIPEC remains unclear.
aimsTo evaluate the association between early postoperative lactate dynamics (0-h and 12-h lactate levels and lactate clearance) and AKI, defined by KDIGO criteria, in patients undergoing HIPEC. Secondary aims were to assess the relationship of lactate dynamics with ICU length of stay and mortality.
methodsThis retrospective, single- center cohort included 98 patients who underwent CRS-HIPEC between 2019 and 2024. Demographic, perioperative, and postoperative data were collected. Lactate clearance was calculated from 0-h and 12-h lactate values. AKI was defined according to KDIGO criteria. Statistical comparisons and ROC curve analysis were performed, with p < 0.05 considered significant.
resultsAKI occurred in 32.7% of patients. Intraoperative inotrope use was significantly associated with AKI. Patients with AKI had longer ICU length of stay and higher mortality. The 12-h lactate level was significantly higher in the AKI group and showed limited but significant predictive value for AKI (AUC = 0.623). A threshold above 1.9 mmol/L indicated higher risk. Elevated 12-h lactate and negative lactate clearance were also strong predictors of mortality.
conclusionPostoperative 12-h lactate was associated with AKI and strongly predicted mortality, whereas lactate clearance was not predictive of AKI. Elevated postoperative 12-h lactate and negative clearance may serve as simple and early biomarkers for risk stratification following HIPEC.
Indexed as
Identifiers
41231421What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.