Trial reportThe Journal of nutrition2026
Plasma and Urinary Metabolomic Profiles Associated with the Salt Sensitivity of Blood Pressure in the Dietary Approaches to Stop Hypertension-Sodium Trial.
Trial report in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000608 (Dietary Patterns, Sodium Intake and Blood Pressure), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Patterns, Sodium Intake and Blood Pressure (DASH - Sodium)
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe salt sensitivity of blood pressure (SSBP) affects ∼50% of hypertensive patients and is an independent risk factor for cardiovascular disease. The SSBP also affects ∼25% of normotensives, which increases their risk of hypertension. Currently, there are no validated biomarkers for assessing the SSBP.
objectivesThis study sought to identify plasma and urine metabolomic profiles that are unique to salt-sensitive (SS) subjects and to identify potential biomarkers for the assessment of the SSBP.
methodsUntargeted metabolomic profiling was conducted on plasma and urine samples from salt-sensitive and salt-resistant (SR) participants from the Dietary Approaches to Stop Hypertension-Sodium Trial control diet arm with a low-sodium (LS) or high-sodium (HS) content. Study 1 examined paired, within-participant plasma (59 SS and 45 SR) and urine (45 SS and 40 SR) samples after a LS or HS control diet intervention. Study 2 examined plasma and urine samples in participants (45 SS and 40 SR) after a HS control diet intervention. To investigate differences in metabolites, principal component analysis and orthogonal partial least squares discriminant analyses were conducted. Differential metabolite expression analysis was conducted to determine statistical significance.
resultsDifferential expression analysis revealed 11 and 10 plasma metabolites differed between control-LS and control-HS diets in SS and SR participants, respectively (P < 0.05), with 9 metabolites changing similarly. No differences were observed in urine metabolites between control-LS and control-HS diets. Metabolomic profiling showed that SS and SR participants had 11 plasma and 12 urine metabolites that were differentially expressed on a control-HS diet (P < 0.05).
conclusionsWe identified multiple plasma and urinary metabolites that were associated with the SSBP during a control-HS dietary intervention, which is representative of a typical western diet. The identified metabolites represent potential biomarkers of the SSBP. This trial was registered at www. CLINICALTRIALS: gov as NCT00000608 (https://www. CLINICALTRIALS: gov/study/NCT00000608).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.