Evidence map›Paper›PMID 41233546›Full record

ArticleNature2026

Physiology and immunology of a pig-to-human decedent kidney xenotransplant.

Robert A Montgomery, Jeffrey M Stern, Farshid Fathi, Nathan Suek, Jacqueline I Kim, Karen Khalil, Benjamin Vermette, Vasishta S Tatapudi, Aprajita Mattoo, Edward Y Skolnik and 43 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. The Top 12 Most Impactful Papers in Clinical Transplantation in 2025: TI Editors' Choice.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

53 authors.

Robert A Montgomery *New York University Langone Transplant Institute, New York, NY, USA. Robert.Montgomery@nyulangone.org.ORCID http://orcid.org/0000-0003-2728-4552
Jeffrey M Stern *New York University Langone Transplant Institute, New York, NY, USA.ORCID http://orcid.org/0000-0001-5588-0357
Farshid Fathi *Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-0280-7612
Nathan Suek *Columbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.
Jacqueline I KimDepartment of Surgery, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-8165-525X
Karen KhalilNew York University Langone Transplant Institute, New York, NY, USA.
Benjamin VermetteColumbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-4292-1281
Vasishta S TatapudiNew York University Langone Transplant Institute, New York, NY, USA.
Aprajita MattooNew York University Langone Transplant Institute, New York, NY, USA.
Edward Y SkolnikDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Ian S JaffeDepartment of Surgery, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7309-308X
Imad AljabbanNew York University Langone Transplant Institute, New York, NY, USA.
Tal EitanNew York University Langone Transplant Institute, New York, NY, USA.ORCID http://orcid.org/0000-0002-0811-6871
Shivani BisenNew York University Grossman School of Medicine, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2585-0154
Elaina P WeldonNew York University Langone Transplant Institute, New York, NY, USA.
Valentin GoutaudierUniversité Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration (PITOR), Paris, France.
Erwan MorgandUniversité Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration (PITOR), Paris, France.
Fariza MezineUniversité Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration (PITOR), Paris, France.
Alessia GiarraputoUniversité Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration (PITOR), Paris, France.
Idris BoudhabhayTeam Inflammation Complement and Cancer, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université Paris Cité, Paris, France.
Patrick BrunevalUniversité Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration (PITOR), Paris, France.ORCID http://orcid.org/0000-0002-2350-2914
Aurelie SannierUniversité Paris Cité, INSERM U970, Paris Institute for Transplantation and Organ Regeneration (PITOR), Paris, France.
Kevin BreenColumbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.
Yasmeen S SaadColumbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-6612-7985
Constanza Bay MuntnichColumbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA.
Simon H WilliamsNew York University Langone Transplant Institute, New York, NY, USA.
Weimin ZhangInstitute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8836-1438
Larisa KagermazovaInstitute for Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0004-7494-284X
Eloi SchmauchNew York University Langone Transplant Institute, New York, NY, USA.
Chandra GoparajuDepartment of Cardiothoracic Surgery, New York University Langone Health, New York, NY, USA.
Rebecca DieterNew York University Langone Transplant Institute, New York, NY, USA.
Nikki LawsonNew York University Langone Transplant Institute, New York, NY, USA.
Amy DandroRevivicor, Blacksburg, VA, USA.
Ana Laura Fazio-KrollRevivicor, Blacksburg, VA, USA.
Lars BurdorfRevivicor, Blacksburg, VA, USA.
David AyaresRevivicor, Blacksburg, VA, USA.
Marc LorberUnited Therapeutics Corporation, Silver Spring, MD, USA.
Dorry SegevDepartment of Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Nicole AliNew York University Langone Transplant Institute, New York, NY, USA.
David S GoldfarbDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-9215-1273
Victoria CostaDepartment of Pathology, New York University Langone Health, New York, NY, USA.
Timothy HilbertDepartment of Pathology, New York University Langone Health, New York, NY, USA.
Sapna A MehtaNew York University Langone Transplant Institute, New York, NY, USA.
Ramin S HeratiDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2613-4050
Harvey I PassDepartment of Cardiothoracic Surgery, New York University Langone Health, New York, NY, USA.
Ming WuDepartment of Pathology, New York University Langone Health, New York, NY, USA.
Jef D BoekeDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5322-4946
Brendan KeatingDepartment of Surgery, New York University Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-3320-3723
Massimo MangiolaNew York University Langone Transplant Institute, New York, NY, USA.ORCID http://orcid.org/0000-0002-5406-4005
Philip M SommerNew York University Langone Transplant Institute, New York, NY, USA.
Alexandre LoupyTeam Inflammation Complement and Cancer, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université Paris Cité, Paris, France.
Adam GriesemerNew York University Langone Transplant Institute, New York, NY, USA.ORCID http://orcid.org/0000-0003-4894-2024
Megan SykesColumbia Center for Translational Immunology, Department of Medicine, Columbia University, New York, NY, USA. Megan.Sykes@columbia.edu.ORCID http://orcid.org/0000-0002-4947-4376

Funding

Lung Biotechnology and from ChoironeX
6 · The paper itself

Abstract

Xenotransplantation of genetically modified pig kidneys offers a solution to the scarcity of organs for patients with end stage renal disease

Indexed as

Kidney TransplantationTransplantation, HeterologousAnimalsAnimals, Genetically ModifiedAntilymphocyte SerumComplement C3CreatinineFemaleGalactosyltransferasesGene Knockout TechniquesGraft RejectionHeterograftsHumansImmunosuppression TherapyKidneyMalealpha-1,3-galactosyltransferase 1, porcineAntilymphocyte SerumComplement C3CreatinineGalactosyltransferases

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.