Evidence map›Paper›PMID 41233547›Full record

ArticleNature2026

Multi-omics analysis of a pig-to-human decedent kidney xenotransplant.

Eloi Schmauch, Brian D Piening, Alexa K Dowdell, Maedeh Mohebnasab, Simon H Williams, Alexey Stukalov, Fred L Robinson, Robin Bombardi, Ian Jaffe, Karen Khalil and 63 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Future of xenotransplantation in Korea.Clinical transplantation and research · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. The Top 12 Most Impactful Papers in Clinical Transplantation in 2025: TI Editors' Choice.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors.

Eloi Schmauch *NYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-2123-8777
Brian D Piening *Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0000-0002-2683-8157
Alexa K DowdellEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0000-0003-4866-6293
Maedeh MohebnasabDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-6623-9514
Simon H WilliamsNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Alexey StukalovSeer, Redwood City, CA, USA.ORCID 0000-0002-4981-8124
Fred L RobinsonEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.
Robin BombardiIllumina, San Diego, CA, USA.
Ian JaffeNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-7309-308X
Karen KhalilNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Jacqueline KimNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-8165-525X
Imad AljabbanNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Tal EitanNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-0811-6871
Darragh P O'BrienNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-4924-7795
Mercy RophinaNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Chan WangDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Alexandra Q BartlettEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0000-0001-7912-6084
Francesca ZanoniNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-9567-6713
Jon AlbayDepartment of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
David AndrijevicDepartment of Surgery, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-5703-3837
Berk MadenNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0009-0005-8941-7367
Vincent MauduitNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Susanna VikmanNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Diana ArgibayNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Zasha ZayasNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Leah WuNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Kiana MoiNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Billy LauDepartment of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA.
Weimin ZhangInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-8836-1438
Loren GragertDepartment of Pathology and Laboratory Medicine, Tulane University, New Orleans, LA, USA.ORCID 0000-0002-5945-6518
Elaina WeldonNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Hui GaoNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Lauren HamiltonEarle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.ORCID 0009-0007-4167-9637
Larisa KagermazovaInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0009-0004-7494-284X
Brendan R CamellatoInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-7061-3051
Divya GandlaNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Riyana BhattNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Sarah GaoNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-1157-3942
Rudaynah A Al-AliDepartment of Internal Medicine, King Fahd Hospital of the University, Alkhobar, Saudi Arabia.
Alawi H HabaraDepartment of Clinical Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.ORCID 0000-0002-5384-8764
Andrew ChangNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Shadi FerdosiSeer, Redwood City, CA, USA.
Han M ChenDepartment of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Jennifer D MotterDepartment of Surgery, NYU Grossman School of Medicine, New York, NY, USA.
Scott C ThomasDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.ORCID 0000-0001-5140-6033
Deepak SaxenaDepartment of Surgery, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-5506-5827
Robert L FairchildDepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Alexandre LoupyParis Transplant Group, INSERM, Paris, France.
Adriana HeguyGenome Technology center, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-2836-6683
Ali CrawfordIllumina, San Diego, CA, USA.
Serafim BatzoglouSeer, Redwood City, CA, USA.
Michael P SnyderDepartment of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0784-7987
Asim SiddiquiSeer, Redwood City, CA, USA.ORCID 0000-0002-0359-2334
Michael V HolmesMedical Research Council, Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Anita S ChongDepartment of Surgery, The University of Chicago, Chicago, IL, USA.ORCID 0000-0003-0460-0196
Minna U KaikkonenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-6294-0979
Suvi Linna-KuosmanenA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-3278-2727
David AyaresRevivicor, Blacksburg, VA, USA.
Marc LorberUnited Therapeutics, Silver Spring, MD, USA.
Anoma NelloreNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Edward Y SkolnikDepartment of Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Aprajita MattooNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Vasishta S TatapudiNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Ryan TaftIllumina, San Diego, CA, USA.
Massimo MangiolaNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-5406-4005
Qian GuoNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.
Ramin S HeratiDepartment of Medicine, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-2613-4050
Jeffrey SternNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-5588-0357
Adam GriesemerNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-4894-2024
Manolis KellisBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7113-9630
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY, USA.ORCID 0000-0001-5322-4946
Robert A MontgomeryNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-2728-4552
Brendan J KeatingNYU Langone Transplant Institute, NYU Langone Health, New York, NY, USA. brendan.keating@nyulangone.org.ORCID 0000-0002-3320-3723

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Project 2U19AI191396 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Brendan James Keating · 2025 to 2026
$8.5M
Multi-omic Biomarker Discovery and Validation in Heart Transplant Patient PopulationsR01AI144522 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DENG, MARIO C., KEATING, BRENDAN JAMES · 2020 to 2024
$4.0M
The EDRN Mesothelioma Biomarker Discovery LaboratoryU01CA214195 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PASS, HARVEY IRA, YANG, HAINING · 2016 to 2021
$3.5M
BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
NCI NIH HHS P30 CA016087NCI NIH HHS U01 CA214195NCRR NIH HHS S10 RR027050NIAID NIH HHS R01 AI144522NIAID NIH HHS U19 AI191396NIH HHS S10 OD020056
6 · The paper itself

Abstract

Organ shortage remains a major challenge in transplantation, and gene-edited pig organs offer a promising solution

Indexed as

Kidney TransplantationMultiomicsProteomicsTransplantation, HeterologousAnimalsFemaleGraft RejectionHeterograftsHumansKidneyMacrophagesMaleSwineT-Lymphocytes

Identifiers

PMID41233547
PMCPMC12805800

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.