Evidence map›Paper›PMID 41233677›Full record

ArticleGeroScience2025

Mitochondrial dysfunction drives age-related degeneration of the thoracic aorta.

Arjune S Dhanekula, Benjamin R Harrison, Gavin Pharaoh, Aurora Mattson-Hughes, Stefano Tarantini, Rudolph Stuppard, Scott C DeRoo, Christopher R Burke, Billiana Hwang, Jay D Pal and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Arjune S DhanekulaDivision of Cardiothoracic Surgery, University of Washington, Seattle, WA, USA. adhaneku@uw.edu.ORCID http://orcid.org/0000-0002-3554-7060
Benjamin R HarrisonDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Gavin PharaohDepartment of Radiology, University of Washington, Seattle, WA, USA.
Aurora Mattson-HughesDepartment of Radiology, University of Washington, Seattle, WA, USA.
Stefano TarantiniVascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Rudolph StuppardDepartment of Radiology, University of Washington, Seattle, WA, USA.
Scott C DeRooDivision of Cardiothoracic Surgery, University of Washington, Seattle, WA, USA.
Christopher R BurkeDivision of Cardiothoracic Surgery, University of Washington, Seattle, WA, USA.
Billiana HwangDivision of Cardiothoracic Surgery, University of Washington, Seattle, WA, USA.
Jay D PalDivision of Cardiothoracic Surgery, University of Washington, Seattle, WA, USA.
Michael S MulliganDivision of Cardiothoracic Surgery, University of Washington, Seattle, WA, USA.
David J MarcinekDepartment of Radiology, University of Washington, Seattle, WA, USA.

Funding

PROGRAM ENRICHMENTP30AG013280 · UNIVERSITY OF WASHINGTON · 1995 to 2025
$6.6M
Mechanisms underlying reversal of cardiac aging by urolithin a treatmentR01AG081395 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$635k
Aging Mitochondrial InteractomeR01AG078279 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$534k
NIA NIH HHS AG066574NIA NIH HHS AG078279NIA NIH HHS P30 AG013280NIA NIH HHS R01 AG078279NIA NIH HHS R01 AG081395
6 · The paper itself

Abstract

This study investigated the role of mitochondrial function in aortic aging. As the aorta ages, it becomes stiffer and less compliant, increasing the risk of aneurysmal disease, hypertension, and diastolic dysfunction. Given the role of mitochondrial dysfunction in non-age related aortopathies and as a hallmark of aging, we investigated its contribution to the aging aorta. Both male and female young (5-6 month) and aged (24-25 month) C57Bl/6 J mice received mitochondrial-targeted peptide elamipretide (ELAM; SS-31) for 8 weeks. ELAM restored complex II-linked respiration in aged mice to values seen in young mice, while also improving relative phosphorylative flux. ELAM treatment also reduced inflammatory MMP9 expression and elastin breaks in aged mice. Bulk RNAseq analysis revealed that ELAM treatment significantly affected the aortic transcriptome in an age-dependent manner, reducing the expression of senescent and associated pro-inflammatory genes. Mitochondrial dysfunction thus drives aortic aging and is a potential therapeutic target for future study.

Indexed as

AortaMitochondriaSenescenceVascular biology

Identifiers

PMID41233677

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.