ArticleLipids in health and disease2025
Triglyceride-glucose index and postoperative delirium: a retrospective study exploring a lipid-related marker in neuropsychiatric risk stratification after gastric surgery.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Metabolic syndrome and perioperative neurocognitive disorders: epidemiology, mechanisms, and interventions.Frontiers in neuroscience · 2026Review
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Abstract
backgroundDelirium is a common neuropsychiatric complication following major gastrointestinal surgery and is associated with poor postoperative outcomes. Patients undergoing gastric surgery often experience significant metabolic stress and insulin resistance, which may contribute to delirium. The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance, but its predictive value for postoperative delirium in gastric surgery patients remains unclear.
methodsThis retrospective study used data from the MIMIC-IV database and included 819 ICU patients after gastric surgery. Exposure was the triglyceride-glucose (TyG) index from first available labs; outcome was ICU delirium assessed by CAM-ICU. Associations were examined with multivariable logistic regression, with standard covariate adjustment.
resultsIncreased ICU delirium was independently linked to a higher TyG index (OR = 1.25, 95% CI: 1.01-1.56). RCS revealed a U-shaped relationship. The association remained stable after PSM and across multiple subgroups. SHAP analysis confirmed TyG as a meaningful predictor.
conclusionA greater TyG index was linked in this retrospective analysis to a higher incidence of postoperative delirium in individuals after gastric surgery. These findings support preoperative risk stratification and targeted monitoring to enhance peri-operative safety and recovery in gastric surgery patients, and prospective studies are warranted to validate its clinical utility.
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