The multifaceted roles of fatty acids and their dysregulation in obese mothers: potential implications for infant development.

Boqun Liu, Yuqing Liu, Chuang Zhai, Xuan Wu, Yanmei Wang, Xibi Fang

Abstract readReview

In one paragraph

Review in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

DHA: Nutritional Programming During the First 1000 Days of Life.Nutrients · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Boqun LiuCollege of food Science and Engineering, Jilin University, Changchun, 130062, China.

Yuqing LiuCollege of food Science and Engineering, Jilin University, Changchun, 130062, China.

Chuang ZhaiCollege of food Science and Engineering, Jilin University, Changchun, 130062, China.

Xuan WuCollege of food Science and Engineering, Jilin University, Changchun, 130062, China.

Yanmei WangDepartment of Clinical Nutrition, Jilin Provincial People's Hospital, Changchun, 130021, China.

Xibi FangDepartment of Animal Science, Jilin University, Changchun, 130062, China. fangxibi@jlu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities,China 2023-JCXK-20the Jilin Province Science and Technology Development Plan Project 20240404037ZP

6 · The paper itself

Abstract

The increasing global rates of obesity underscore the need to investigate its impact on infant health. Breast milk, crucial for infant nutrition, varies in composition due to maternal obesity during pregnancy. Research reveals that obese or overweight mothers tend to have higher saturated fatty acids (SFAs) levels, like palmitic and myristic acids, while stearic acid levels are lower. Monounsaturated fatty acids (MUFAs), particularly oleic acid in milk, decline in obesity. Polyunsaturated fatty acids (PUFAs), essential for infant brain and nervous system development, show imbalances in obese mothers, with an increased omega-6 (ω-6): omega-3 (ω-3) ratio and reduced levels of key ω-3 fatty acids such as α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These changes could disrupt normal immune and nervous system development in infants. This review highlights the critical impact of maternal obesity on breast milk quality.

Indexed as

Breast milkFatty acidsInfant healthMaternal obesity

Identifiers

PMID41233879

DOI10.1186/s12986-025-01009-9

PMCPMC12613526

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.