ArticleJournal of translational medicine2025
Pyrrolidine dithiocarbamate accelerates early recovery of intestinal microvascular oxygenation in a reversible model of hemorrhagic shock in rats.
Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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12 authors.
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Abstract
backgroundImproving intestinal tissue integrity appears to be crucial for maintaining global homeostasis in patients suffering from hemorrhagic shock. Since depletion of regional oxygen reserve might lead to cell death and tissue injury, the maintenance of regional tissue oxygenation appears to prevent intestinal mucosa from barrier shut down. Pyrrolidine dithiocarbamate (PDTC), an inducer of heme oxygenase-1 (HO-1), was reported to improve tissue integrity in various tissues under conditions of restricted oxygen delivery. Therefore, we investigated the effect of PDTC pretreatment on intestinal microvascular oxygenation (µHbO
methods40 male Wistar rats were randomized into 4 experimental groups and received standardized instrumentation under general anesthesia. Hemorrhagic shock was induced by arterial blood withdrawal (MAP: 40 ± 5 mmHg; 1 h). Subsequently, shed blood was transfused and animals were observed for 2 h. Control animals were observed for 3 h without the induction of hemorrhagic shock. PDTC (100 mg·kg
resultsHemorrhagic shock decreased intestinal µHbO
conclusionThe gastrointestinal tract is at persistent risk to develop tissue injury during hemorrhagic shock. The systemic application of PDTC is a promising pharmacological strategy to improve intestinal oxygen reserve during hemorrhagic shock and subsequent blood transfusion. This might lead to reduced intestinal tissue injury, maintain global homeostasis and reduce morbidity of patients suffering from hemorrhagic shock. However, the exact mechanism by which PDTC pretreatment improves intestinal oxygen reserve has to be elucidated in further studies since neither microvascular nor mitochondrial function was altered after PDTC application in this study. Furthermore, observed effects might include both HO-1-dependent and HO-1-independent mechanisms.
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