Evidence map›Paper›PMID 41234226›Full record

ArticleFrontiers in endocrinology2025

Relationship between serum LDH levels and diabetic peripheral neuropathy in type 2 diabetic patients.

Meng Sun, Zhaodi Wang, Xu Yan, Hangyu Shen, Hongqiao Yang, Yuxia Qi, Xiang Gao, Yi Huang, Jie Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Meng Sun *Ningbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Zhaodi Wang *Department of Internal Medicine, Qingdao Public Health Clinical Center, Qingdao, Shandong, China.
Xu YanNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Hangyu ShenNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Hongqiao YangNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Yuxia QiDepartment of Internal Medicine, Qingdao Public Health Clinical Center, Qingdao, Shandong, China.
Xiang GaoNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Yi HuangNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Jie SunNingbo Key Laboratory of Nervous System and Brain Function, Department of Neurosurgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetic peripheral neuropathy (DPN) is commonly observed as a long-term complication in patients with type 2 diabetes mellitus (T2DM). Recent evidence suggests that metabolic disturbances and chronic inflammation may contribute to its development. Lactate dehydrogenase (LDH), a key enzyme in glycolysis, may reflect underlying metabolic stress and inflammation, but its association with DPN remains unclear. Methods: In this cross-sectional study, 2,060 patients with T2DM were analyzed to explore the relationship between serum LDH levels and DPN. Logistic regression and restricted cubic spline (RCS) models were used to assess linear and non-linear associations. Participants were also stratified by age, sex, hypertension, and HbA1c levels for subgroup analyses. Results: Among the study population, 724 (35.1%) had DPN. Higher LDH levels were independently associated with an increased risk of DPN after adjusting for potential confounders (adjusted OR per 1 U/L increase: 1.00; 95% CI: 1.00-1.01; P = 0.01). RCS analysis showed a non-linear relationship, with a threshold at 142 U/L. Participants with LDH >142 U/L had significantly higher odds of DPN (adjusted OR: 1.21; 95% CI: 1.02-1.48; P = 0.033). This association was consistent across subgroups. Conclusion: Serum LDH levels are significantly and non-linearly associated with DPN in individuals with T2DM. LDH may serve as a simple and cost-effective biomarker for identifying patients at elevated risk of neuropathy, warranting further prospective validation.

Indexed as

Diabetes Mellitus, Type 2Diabetic NeuropathiesL-Lactate DehydrogenaseAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsBiomarkersL-Lactate Dehydrogenasebiomarkerdiabetic peripheral neuropathylactate dehydrogenaserisk assessmenttype 2 diabetes mellitus

Identifiers

PMID41234226
PMCPMC12604985

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.