ReviewFrontiers in endocrinology2025
Exercise reshapes gut microbiota to ameliorate core symptoms in PCOS: molecular mechanisms and therapeutic implications.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Decoding the gut-adipose-ovary axis in polycystic ovary syndrome: from metabolic dysregulation to oncological risk modulation.Frontiers in microbiology · 2026Review
- The impact of obesity-related systemic inflammation on the efficacy, toxicity, and biomarkers of immune checkpoint inhibitors in lung cancer: from mechanisms to clinical management.Frontiers in immunology · 2026Review
- Classification of intestinal inflammation driven by gut microbiota metabolites: a new paradigm for precision treatment of cardiovascular diseases.Frontiers in microbiology · 2026Review
- Lobetyolin reshapes gut microbiota and bile acid metabolism to improve androgen-driven PCOS phenotypes in mice.Frontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder characterized by Insulin Resistance (IR), hyperandrogenism, and ovulatory dysfunction, with gut dysbiosis emerging as a key pathophysiological driver. Exercise, a non-pharmacological intervention, ameliorates PCOS symptoms, yet the molecular mechanisms linking exercise-induced gut microbiota remodeling to metabolic improvements remain elusive. Objective: This review synthesizes evidence on how exercise reshapes gut microbiota to reverse core PCOS pathologies through integrated molecular pathways. Results: Exercise enriches beneficial taxa (e.g., Conclusion: Exercise remodels the gut microbiota-metabolism-immune network to reverse PCOS pathophysiology. Targeting microbial metabolites (e.g., butyrate, BAs) or their receptors (FXR, GPR43) offers novel therapeutic strategies. Future research must address PCOS heterogeneity and optimize exercise protocols for microbiota-directed precision medicine.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.