Comparative assessment of various protein isolates underpinning cognitive modulation: An interplay of neurobiological markers and gut-brain axis.

Sundas Hina, Zhicheng Li, Zhang Jing, Saddam Mustafa, Ding Yi, Zhao Yuan, Wupeng Ge

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Article in Current research in food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Sundas HinaCollege of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, PR China.

Zhicheng LiCollege of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, PR China.

Zhang JingCollege of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, PR China.

Saddam MustafaKey Laboratory of Jianghuai Agricultural Product Fine Processing and Resource Utilization, Ministry of Agriculture and Rural Affairs, Anhui Engineering Research Center for High Value Utilization of Characteristic Agricultural Products, College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei, PR China.

Ding YiCollege of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, PR China.

Zhao YuanCollege of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, PR China.

Wupeng GeCollege of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary composition significantly influences gut microbiota, which modulates neurodevelopment and cognitive functions via the gut-brain axis. While various protein sources have demonstrated neuroprotective effects, their impact during early developmental stages remains underexplored. This study evaluated the effects of fish protein isolate (FPI), soy protein isolate (SPI), and egg white isolate (EPI) on cognitive functions in juvenile mice. Behavioral evaluations, including the Morris water maze, Y-maze, and novel object recognition tests, were completed during the feeding trial. FPI supplementation significantly enhanced cognitive performance compared to SPI and EPI groups. Biochemical analyses revealed that FPI normalized cholinergic activity and oxidative stress markers in the mice brains. The FPI group exhibited higher levels of synaptophysin and postsynaptic density proteins in the hippocampus, along with increased antioxidant enzyme levels and lower amounts of malondialdehyde, compared to the SPI and EPI groups, respectively. Synaptic plasticity was enhanced by FPI supplementation. Moreover, the same FPI diet upregulated the levels of brain-derived neurotrophic factor and doublecortin, while downregulating the activation of astrocytes and microglia, when compared to SPI and EPI groups. Additionally,

Indexed as

Cognitive developmentGut-brain axisMicrobiota modulationNeurogenesis and synaptic plasticityProtein isolates

Identifiers

PMID41234364

DOI10.1016/j.crfs.2025.101232

PMCPMC12607091

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LicenceCC BY-NC-ND

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