Evidence map›Paper›PMID 41234632›Full record

ArticleBiochemistry and biophysics reports2025

Deactivation of CK1α enhances the anti-cancer effects of salinomycin in colorectal cancer HCT116 cells.

Sara Khakshournia, Morvarid Siri, Mozhdeh Zamani, Farzaneh Bozorg-Ghalati, Zahra Mojtahedi, Somayeh Igder, Negar Azarpira, Pooneh Mokarram

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara KhakshourniaAutophagy Research Center, Shiraz University of Medical Sciences, PO Box: 71345-1849, Shiraz, Iran.
Morvarid SiriAutophagy Research Center, Shiraz University of Medical Sciences, PO Box: 71345-1849, Shiraz, Iran.
Mozhdeh ZamaniAutophagy Research Center, Shiraz University of Medical Sciences, PO Box: 71345-1849, Shiraz, Iran.
Farzaneh Bozorg-GhalatiAutophagy Research Center, Shiraz University of Medical Sciences, PO Box: 71345-1849, Shiraz, Iran.
Zahra MojtahediSchool of Public Health, University of Nevada, PO Box: 89154, Las Vegas, NV, 89154, USA.
Somayeh IgderDepartment of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, PO Box: 61355- 45, Ahvaz, Iran.
Negar AzarpiraAutophagy Research Center, Shiraz University of Medical Sciences, PO Box: 71345-1849, Shiraz, Iran.
Pooneh MokarramAutophagy Research Center, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, PO Box: 71345-1849, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salinomycin (Sal), an ion-carrier antibiotic, effectively suppresses cancer growth and metastasis through autophagy or ferroptosis induction, thereby overcoming drug resistance. D4476, a selective inhibitor of casein kinase 1 alpha (

Indexed as

AutophagyCasein kinase 1 alphaColorectal cancerFerroptosisHCT116 cellsSalinomycin

Identifiers

PMID41234632
PMCPMC12605655

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.