Evidence map›Paper›PMID 41234692›Full record

ArticleFrontiers in physiology2025

Muscle energetics and the cardiovascular response to isometric exercise and post-exercise circulatory occlusion following exercise-induced muscle damage: insights from multiparametric MRI.

Fabio Zambolin, Jean-Christophe Lagacé, Susan Pinner, James McStravick, Fiona E Smith, Aneurin J Kennerley, Jamie S McPhee

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fabio ZambolinDepartment of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom.
Jean-Christophe LagacéFaculty of Physical Activity Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
Susan PinnerDepartment of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom.
James McStravickManchester Metropolitan University Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom.
Fiona E SmithDepartment of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom.
Aneurin J KennerleyDepartment of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom.
Jamie S McPheeDepartment of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Skeletal muscles damaged by exercise exhibit disturbed energy metabolism and microvascular function for several days. However, it remains unclear whether these local changes might affect systemic cardiovascular responses to exercise. The present study aimed to investigate whether damaged muscles show changes in energy metabolism and oxygenation that influence systemic cardiovascular responses to exercise and post-exercise circulatory occlusion (PECO). Methods: A novel multi-parametric magnetic resonance imaging and spectroscopy approach was applied. Twelve healthy male participants completed assessments before and 48 h after 40 min of downhill running (20% decline). The assessments included muscle function, inflammation, and multi-parametric imaging at rest, exercise, and post-exercise occlusion using Results: Forty-eight hours after downhill running, muscle inflammation and Na Conclusion: Our multi-parametric MRI approach provides new insights into the local effects of muscle damage on energy metabolism, oxygenation, and Na

Indexed as

delayed onset of muscle sorenessexercise-induced muscle damagegroup III–IV muscle afferentsmagnetic resonance spectroscopymuscle inflammationmuscle metabolismmuscle oxygenation

Identifiers

PMID41234692
PMCPMC12605002

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.