ArticleInternational journal of women's health2025
Identification of Key Genes Involved in the Occurrence and Development of Endometrial Cancer.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Object: Endometrial cancer (EC) is one of the most common gynecologic malignancies, for which endometrial hyperplasia (EH) and type 2 diabetes are established high-risk factors. However, the common molecular mechanisms underlying this association remain poorly understood. This study therefore aimed to identify and validate hub genes linking EH, type 2 diabetes, and EC, and to assess their prognostic value. Methods: Intersection genes among EH and EC DEGs (GSE106191) and type 2 diabetes-related genes (GeneCards) were screened. A prognostic model was constructed via Lasso-Cox regression in TCGA-UCEC. Functional enrichment (GO and KEGG) analyzed the prognostic model. The PPI network identified hub genes within the prognostic model. Subsequent prognostic analysis in TCGA-UCEC validated key hub genes. Their expression was further analyzed across GSE106191 and TCGA-UCEC datasets and confirmed via immunohistochemistry. Correlations with clinical features (age, stage, grade, TP53 mutation, weight) in EC were assessed using UALCAN. Results: One hundred and sixty-two intersection genes were identified. The 16-gene prognostic model stratified EC patients into high/low-risk groups with significantly distinct overall survival (HR = 3.475, Conclusion:
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