ArticleCurrent genomics2025
Causal Associations of Smoking, Alcohol, Obesity, Sedentary Behavior, Hypertension, and Hyperglycemia With Retinal Vein Occlusion: A Mendelian Randomization Study.
Article in Current genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Retinal Vein Occlusion (RVO) is a common and main cause of blindness. Causal, possible risk variables must be identified to develop preventative strategies for RVO. Thus, we decided to evaluate whether smoking, alcohol, obesity, sedentary behaviour, hypertension, and hyperglycemia are associated with increased risk of RVO. Methods: The data sources of Mendelian Randomization (MR) study included FinnGen consortium and the original GWAS article. A total of 130,604 cases with RVO from FinnGen consortium and 12,136 cases with RVO from the original GWAS article. The exposures of this MR study included smoking, alcoholic consumption, obesity, sedentariness, hypertension, and hyperglycemia. The outcome of this MR study was RVO. Results: Genetic predispositions to alcohol consumption (OR (odds ratio), 1.124; 95%CI, 1.007-1.254; Conclusion: This MR analysis provides genetic evidence that increased alcohol consumption and hyperglycemia may be causal risk factors for RVO. In addition, no genetic evidence in this MR analysis supported that there were causal associations between smoking, sedentariness, obesity and hypertension with RVO.
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