ArticleToxicology research2025
Role of aspartate aminotransferase in predicting Pediatric carbon monoxide poisoning outcomes: a Multicenter retrospective cohort study.
Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This multicenter retrospective cohort study investigated prognostic markers for clinical outcomes and delayed neurological sequelae (DNS) in pediatric patients with carbon monoxide poisoning (COP). We analyzed data from patients under 17 yr of age who presented to emergency departments between January 2007 and October 2018 with a carboxyhemoglobin (COHb) level exceeding 10%. A total of 162 cases were included. Clinical and laboratory parameters such as oxygen saturation (SpO₂), Glasgow Coma Scale (GCS), white blood cell (WBC) count, aspartate aminotransferase (AST), red cell distribution width (RDW), and COHb levels were evaluated. Poor outcomes were defined as death or a GCS score below 13 at discharge. Patients with poor outcomes had significantly lower SpO₂ and GCS scores, and elevated WBC, AST, and RDW levels (all
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