ArticleCardiovascular endocrinology & metabolism2025
High sensitivity C-reactive protein subsequent rise in urine albumin/creatinine ratio/fall in estimated glomerular filtration rate over 24 years in people with type 2 diabetes.
Article in Cardiovascular endocrinology & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The insulin-like growth factor system and the progression of renal complications of type 2 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Systemic inflammation, which can be measured by high-sensitivity C-reactive protein (hsCRP), may play a crucial role in the progression of chronic kidney disease (CKD) in people with type 2 diabetes (T2D). In this study, we report longitudinal outcomes from 718 individuals with T2D, followed up for up to 24 years, to assess how hsCRP influences the development and progression of CKD, measured by urine albumin-to-creatinine ratio (uACR)/estimated glomerular filtration rate (eGFR). Longitudinal renal function analysis showed numerical trends towards greater mean eGFR decline (-20.6 ml/min in the lowest Q1 vs. -26.4 ml/min in the highest Q4 baseline hsCRP quartile) and greater fold increase in uACR (1.93 in Q1 vs. 2.91 in Q4) across hsCRP quartiles. However, in multivariate linear regression analyses, baseline hsCRP was not an independent predictor of eGFR decline (
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