Evidence map›Paper›PMID 41235610›Full record

Trial reportClinical implant dentistry and related research2025

Autogenous Demineralized Dentin Graft With High Molecular Weight Hyaluronic Acid in Ridge Preservation: Pilot Trial.

Rahma Hesham, Nesma Shemais, Heba Ahmed Saleh, Karim Fawzy El-Sayed

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical implant dentistry and related research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05613075 (Potential Effect Assessment of Locally Applied Hyaluronic Acid, When Mixed With Autogenous De-mineralized Tooth Graft, for Socket Preservation, in Comparison With the Application of Autogenous De-mineralized Tooth Graft Alone.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05613075 nacompletednot on this map

Potential Effect Assessment of Locally Applied Hyaluronic Acid, When Mixed With Autogenous De-mineralized Tooth Graft, for Socket Preservation, in Comparison With the Application of Autogenous De-mineralized Tooth Graft Alone.

TypeinterventionalSponsorCairo UniversityRan2022 to 2024Enrolled30ConditionsAlveolar Bone Resorption, Socket Preservation, Bone Resorption, Unrestorable DentitionArmstooth extraction and socket preservation with demineralized tooth graft, tooth extraction and socket preservation with demineralized tooth graft with hyaluronic acid
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rahma HeshamOral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Nesma ShemaisOral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Heba Ahmed SalehOral and Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-8794-6266
Karim Fawzy El-SayedOral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-6261-3609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe current trial assessed for the first time radiographic and histological alterations, following alveolar ridge preservation (ARP), using autogenous demineralized dentin graft carried in 0.2% high molecular weight sodium hyaluronate (ADDG+HA; test group) versus autogenous demineralized dentin graft (ADDG, control group) alone. MATERIAL AND

methodsThirty patients (n = 30) with non-restorable single-rooted teeth were randomly assigned into two groups (n = 15/group). Following extraction, ARP was performed using either ADDG solely or ADDG+HA. Bucco-lingual alveolar ridge width (BLRW; primary outcome), buccal (BRH) and lingual ridge height (LRH), percentage of newly formed bone, soft tissue and residual graft in human biopsies histologically, as well as patients' pain and discomfort (all secondary outcomes) were assessed after 6 months at the time of implant placement. Sample bone core biopsies were further collected, processed, and histomorphometrically and SEM analyzed.

resultsFor the ADDG and ADDG+HA groups, the alveolar ridge dimensional changes were comparable, being -1.21 ± 0.77 mm and -1.18 ± 0.86 mm in BLRW, -0.89 ± 0.74 and -0.83 ± 0.85 mm in BRH, and -0.9 ± 0.76 mm and -1.05 ± 1.18 mm in LRH respectively (p > 0.05). Clinically, no complications, pain, or inflammatory responses were reported. Histologically, all samples demonstrated bone growth and socket bone fill, while the ADDG+HA group showed a significantly greater presence of mineralized mature bone, which accounted for 33% ± 8.1% of the specimen after 6 months.

conclusionsBoth ADDG and ADDG+HA demonstrated comparable outcomes in terms of ARP. HA amalgamation with ADDG appears to enhance bone mineralization and maturation, yet without a significant impact on dimensional changes during ARP procedures.

trial registrationNCT05613075.

Indexed as

Alveolar Ridge AugmentationDentinHyaluronic AcidAdultAlveolar Bone LossAlveolar ProcessDental Implantation, EndosseousFemaleHumansMaleMiddle AgedMolecular WeightPilot ProjectsTooth ExtractionHyaluronic Acidautograftclinical trialdentinextractionhyaluronic acidtooth

Identifiers

PMID41235610
PMCPMC12616775

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.