ArticleMolecular medicine reports2026
Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications.
Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The combination of knee osteoarthritis (KOA) and atherosclerosis (AS) is a common multimorbidity. Epidemiological studies have demonstrated the existence of common risk factors, with metabolic syndrome possibly considered the most critical. In the present study, metabolism‑related clinical information was analyzed and metabolic profiles were assessed in healthy controls, patients with KOA, patients with AS and patients with both conditions using untargeted serum metabolomics assays. Potential KOA‑AS multimorbidity hub genes were identified using transcriptomics datasets from the Gene Expression Omnibus database and were validated using clinical samples and animal experiments. Finally, the clinical applications of the analyzed biomolecules were predicted. The results showed that the caffeine metabolic pathway was markedly associated with KOA‑AS multimorbidity and caffeine interacted with two potential hub genes (
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