Evidence map›Paper›PMID 41235706›Full record

ArticleEuropean journal of immunology2025

Divergent Effects of Cytomegalovirus and Rheumatoid Arthritis on Senescent CD4

Lea Williams, Ali O Saber, Silina Awad, Xi Su, Asgar Ansari, Ruozhang Xu, Hannah Jung, Anupama Shahane, Joshua F Baker, Laura F Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lea WilliamsDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ali O SaberDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0002-7912-5334
Silina AwadDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xi SuDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Asgar AnsariDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-7073-1154
Ruozhang XuDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hannah JungDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anupama ShahaneDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joshua F BakerDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Laura F SuDepartment of Medicine, Division of Rheumatology, Perelman School of Medicine, Institute for Immunology and Immune Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-0095-4755

Funding

CSRD VA I01 CX001460NIH HHS R01AI66358The CHU fundVA Merit Award I01CX001460
6 · The paper itself

Abstract

Chronic antigen exposure drives CD4⁺ T cell senescence, yet how autoimmunity and persistent viral infections differentially shape T cell differentiation and function remains unclear. Using cytomegalovirus (CMV) and rheumatoid arthritis (RA) as models of chronic immune activation, we performed high-dimensional mass cytometry and functional assays to define their impact on CD4⁺ T cells. In CMV-seropositive individuals, CD27

Indexed as

Arthritis, RheumatoidCD4-Positive T-LymphocytesCellular SenescenceCytomegalovirusCytomegalovirus InfectionsAdultAgedCD28 AntigensCD8-Positive T-LymphocytesCell DifferentiationCytokinesFemaleHerpesvirus 4, HumanHumansLymphocyte ActivationMaleCD28 AntigensCytokines

Identifiers

PMID41235706
PMCPMC12616766

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.