Evidence map›Paper›PMID 41235726›Full record

ArticleAnalytical chemistry2025

Enhancing Hydroxyl Metabolite Analysis through In Situ Derivatization-Enabled Desorption Electrospray Ionization-Mass Spectrometry.

Yen-Chu Lin, Guan-Yuan Chen, Ya-Jin Jheng, Hsiao-Wei Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yen-Chu LinDepartment of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei 112304, Taiwan.ORCID 0009-0004-7026-448X
Guan-Yuan ChenForensic and Clinical Toxicology Center, National Taiwan University, No.7, Zhongshan S. Rd., Zhongzheng Dist., Taipei 100225, Taiwan.ORCID 0000-0002-0505-4089
Ya-Jin JhengForensic and Clinical Toxicology Center, National Taiwan University, No.7, Zhongshan S. Rd., Zhongzheng Dist., Taipei 100225, Taiwan.
Hsiao-Wei LiaoDepartment of Pharmacy, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, No.155, Sec.2, Linong Street, Taipei 112304, Taiwan.ORCID 0000-0003-1760-9536

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlocking the full potential of metabolomics hinges on significantly improving the detection of metabolites, particularly those containing hydroxyl groups, which often remain challenging to ionize. Our previous work established 2-(4-Boronobenzyl) isoquinolin-2-ium bromide (BBII) as a highly effective derivatization reagent for enhancing hydroxyl metabolite sensitivity in liquid chromatography-mass spectrometry. Building upon this, we herein introduce a novel and robust extension: BBII derivatization integrated with desorption electrospray ionization (DESI) for

Indexed as

MetabolomicsSpectrometry, Mass, Electrospray IonizationAnimalsBoron CompoundsBrainGlucoseMiceBoron CompoundsGlucose

Identifiers

PMID41235726
PMCPMC12874211

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.