Evidence map›Paper›PMID 41235815›Full record

ArticleMagnetic resonance in medicine2026

Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.

Gregory Simchick, James Rice, Leah M Gober, Daniel Rice, Jennifer Philip, Alejandro Roldan-Alzate, Diego Hernando

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gregory SimchickRadiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0001-9326-7203
James RiceMechanical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Leah M GoberSurgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Daniel RiceSurgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jennifer PhilipSurgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Alejandro Roldan-AlzateRadiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Diego HernandoRadiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-0016-0317

Funding

Diffusion MRI of the AbdomenR01EB030497 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI HERNANDO, DIEGO · 2021 to 2021
$1.6M
Department of Medical Physics, University of Wisconsin-MadisonDepartment of Radiology, University of Wisconsin-MadisonGE HealthcareNIBIB NIH HHS R01 EB030497NIH HHS R01-EB030497Wisconsin Alumni Research Foundation
6 · The paper itself

Abstract

purposeEvaluate the feasibility of using perfused explanted human livers for validating intravoxel incoherent motion (IVIM).

methodsEight (n = 8) explanted livers from deceased donors were obtained. The portal vein and hepatic artery of each explanted liver were connected to a perfusion system. IVIM data were acquired at four total volumetric flow rates (0, 0.6, 0.9, and 1.2 L/min). For each IVIM dataset, diffusion coefficient (D), relaxation-corrected perfusion signal fraction (F

resultsD was independent of applied flow and total volumetric flow rate (p ≥ 0.30). F

conclusionPerfused explanted human livers from deceased donors may serve as biologically accurate systems for validation of quantitative IVIM techniques.

Indexed as

LiverMagnetic Resonance ImagingAdultBlood Flow VelocityFeasibility StudiesFemaleHumansImage Processing, Computer-AssistedLiver CirrhosisMaleMiddle AgedMotionPerfusionReproducibility of Resultsabdomendeceaseddiffusion weighted imagingdonorex vivointravoxel incoherent motionliverquantitative magnetic resonance imaging

Identifiers

PMID41235815
PMCPMC12850604

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.