ArticleRenal failure2025
Association between estimated plasma volume status and risk of sepsis-associated acute kidney Injury: a retrospective cohort study using the MIMIC-IV database.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Estimated plasma volume status (ePVS) is a simple, useful tool for assessing volume status. However, its prognostic value in sepsis-associated acute kidney injury (SA-AKI) remains unclear. This retrospective cohort study analyzed data from 15,789 patients with SA-AKI extracted from the MIMIC-IV database. The association between ePVS and mortality was evaluated using Cox regression and Kaplan-Meier analysis. Logistic regression was employed to assess the relationship between ePVS and renal recovery. All models were adjusted for demographics, comorbidities, laboratory values, and illness severity scores. Restricted cubic spline (RCS) model was applied to examine potential nonlinear relationships between ePVS and mortality risk. Among 15,789 eligible patients with SA-AKI, the 28-day mortality rate was 23.2%. Multivariate Cox regression analysis revealed that higher ePVS was associated with increased 28-day mortality (HR = 1.05, 95% CI 1.03-1.07,
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