Evidence map›Paper›PMID 41236309›Full record

ArticleFly2025

Innate immunity pathways activate cell proliferation after penetrating traumatic brain injury in adult

Shawn Ahern-Djamali, Khailee Marischuk, Kassi L Crocker, Isabella Peetz, Eli Scott, Grace Boekhoff-Falk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fly, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The Repair Manual of a Fruit Fly Brain.International journal of molecular sciences · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shawn Ahern-DjamaliDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.
Khailee MarischukDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.
Kassi L CrockerDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.
Isabella PeetzGenetics Graduate Training Program, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.
Eli ScottGenetics Graduate Training Program, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.
Grace Boekhoff-FalkDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, WI, USA.ORCID 0000-0002-9877-8309

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Neurogenesis in the adult Drosophila brainR01NS126444 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GRACE E BOEKHOFF-FALK · 2023 to 2026
$1.5M
Mechanisms of Neural RegenerationR21NS102698 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI BOEKHOFF-FALK, GRACE E · 2017 to 2018
$402k
Regeneration in the Adult Drosophila BrainR03NS090190 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI BOEKHOFF-FALK, GRACE E · 2014 to 2015
$151k
NIGMS NIH HHS T32 GM007133NIH HHS P40 OD018537NINDS NIH HHS R01 NS126444NINDS NIH HHS R03 NS090190NINDS NIH HHS R21 NS102698
6 · The paper itself

Abstract

We are utilizing an adult penetrating traumatic brain injury (PTBI) model in Drosophila to investigate regenerative mechanisms after damage to the central brain. Here, we focus on cell proliferation as an early event in the regenerative process. To identify pathways that could trigger cell proliferation following PTBI, we utilized bulk RNA-Seq. We find that transcript levels for components of both Toll and Immune Deficiency (Imd) innate immunity pathways are rapidly and highly upregulated post-PTBI. We then tested mutants for the NF-κB transcription factors of the Toll and Imd pathways, Dorsal-related immunity factor (Dif) and Relish (Rel), respectively. We find that loss of either Dif or Rel results in loss of cell proliferation after injury and identify tissue-specific requirements for Dif and Rel. In addition, while the canonical downstream targets of

Indexed as

Brain Injuries, TraumaticCell ProliferationDrosophilaDrosophila melanogasterImmunity, InnateAnimalsDNA-Binding ProteinsDrosophila ProteinsSignal TransductionTranscription FactorsDif protein, DrosophilaDNA-Binding ProteinsDrosophila ProteinsRel protein, DrosophilaTranscription Factorsadult neurogenesisbrainDrosophilainnate immunitymushroom body

Identifiers

PMID41236309
PMCPMC12622319

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.