Evidence map›Paper›PMID 41236547›Full record

ArticleCellular and molecular life sciences : CMLS2025

Synergetic contributions of Seneca Valley virus 3 C and 3D proteins to induction of ferroptosis for viral replication.

Jiangwei Song, Jingjing Yang, Ruiyi Ma, Zijian Li, Jiayao Su, Shijie Xie, Peipei Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiangwei Song *Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Shuguan Garden Middle Road, Haidian District, Beijing, 100097, China. songjiangwei525@126.com.ORCID http://orcid.org/0000-0002-9759-8875
Jingjing Yang *Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Shuguan Garden Middle Road, Haidian District, Beijing, 100097, China.
Ruiyi Ma *Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Shuguan Garden Middle Road, Haidian District, Beijing, 100097, China.
Zijian LiBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Shuguan Garden Middle Road, Haidian District, Beijing, 100097, China.
Jiayao SuBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Shuguan Garden Middle Road, Haidian District, Beijing, 100097, China.
Shijie XieBeijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, No. 9 Shuguan Garden Middle Road, Haidian District, Beijing, 100097, China.
Peipei Cheng *Beijing Biomedicine Technology Center, Zhaofeng Hua Biotechnology, Beijing, China. chengpeipei1117@163.com.

Funding

National Natural Science Foundation of China 32372980the Outstanding Young Foundation of Beijing Academy of Agriculture and Forestry Sciences YXQN202302the Reform and Development of Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences XMS202503
6 · The paper itself

Abstract

Seneca Valley virus (SVV) infection leads to severe vesicular diseases in pigs, posing a significant threat to the global swine industry. Ferroptosis, a novel form of non-apoptotic cell death, is characterized by iron-dependent phospholipid peroxidation. However, the role of ferroptosis in SVV replication remains poorly understood. In this study, we demonstrate that SVV infection induces ferroptosis, as evidenced by lipid peroxidation, reactive oxygen species (ROS) accumulation, and glutathione (GSH) depletion. The GPX4 and nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy are key contributors to ferroptosis induction. Furthermore, our findings reveal that the SVV 3 C proteinase (3C

Indexed as

FerroptosisPicornaviridaePicornaviridae InfectionsViral ProteinsVirus ReplicationAnimalsFerritinsGlutathioneHumansLipid PeroxidationNuclear Receptor CoactivatorsPhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesSwineFerritinsGlutathioneNuclear Receptor CoactivatorsPhospholipid Hydroperoxide Glutathione PeroxidaseReactive Oxygen SpeciesViral ProteinsFerritinophagyFerroptosisGPX4NCOA4Seneca valley virus (SVV)

Identifiers

PMID41236547
PMCPMC12618751

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.