Evidence map›Paper›PMID 41236579›Full record

ArticleArchives of virology2025

Expression of porcine-derived IgA against PEDV and use of Alg-CS gel to protect the IgA from degradation in simulated gastric fluid.

Jinhua Zhang, Yongliang Zhang, Hao Wu, Shutong Shi, Shengbo Cao, Huanchun Chen, Yunfeng Song

Abstract read
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In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jinhua ZhangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, China.
Yongliang ZhangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, China.
Hao WuState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, China.
Shutong ShiState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, China.
Shengbo CaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, China.
Huanchun ChenState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, China.
Yunfeng SongState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 1 Shizishan Street, Wuhan, Hubei, China. syf@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0002-0954-152X

Funding

National Key Research and Development Program of China 2021YFD1800303National Natural Science Foundation of China 32473044
6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) is a major pathogen that causes severe diarrhea and high mortality in piglets. Immunoglobulin A (IgA) in milk provides more-effective protection for newborn piglets than immunoglobulin G (IgG). In this study, the heavy- and light-chain genes of IgA were cloned from peripheral blood mononuclear cells (PBMCs) and colostrum of pigs immunized with PEDV. Subsequently, the IgA was expressed in Chinese hamster ovary (CHO) cells and purified via affinity chromatography. Three IgA antibodies were obtained (5HV1, 1HV2, and 11HV2), and all three exhibited neutralizing activity against PEDV. The half-maximal effective inhibitory concentrations (IC

Indexed as

Antibodies, ViralCoronavirus InfectionsImmunoglobulin APorcine epidemic diarrhea virusSwine DiseasesAnimalsAntibodies, NeutralizingCHO CellsColostrumCricetulusLeukocytes, MononuclearSwineAntibodies, NeutralizingAntibodies, ViralImmunoglobulin AAlginate-chitosan gelDegradationPEDVPorcine IgASimulated gastric fluid

Identifiers

PMID41236579

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.