Evidence map›Paper›PMID 41236636›Full record

ArticleCellular and molecular life sciences : CMLS2025

γ9δ2 T cells detect mevalonate diphosphate via BTN3A3.

Yiming Jin, Khiem Nguyen, Girija Pawge, Chia-Hung Christine Hsiao, Olga Vinogradova, Andrew J Wiemer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cell stress activates γ9δ2 T cells via endogenous phosphoantigens and butyrophilin complex dynamics.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yiming JinDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.
Khiem NguyenDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.
Girija PawgeDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.
Chia-Hung Christine HsiaoDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.
Olga VinogradovaDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA.
Andrew J WiemerDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, 06269, USA. andrew.wiemer@uconn.edu.ORCID http://orcid.org/0000-0002-3029-1780

Funding

Role of immune modulating butyrophilins in gamma delta T cell activationR01AI150869 · NIAID · UNIVERSITY OF CONNECTICUT STORRS · PI VINOGRADOVA, OLGA, WIEMER, ANDREW J · 2020 to 2024
$2.0M
Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapyR01CA266138 · NCI · UNIVERSITY OF CONNECTICUT STORRS · PI ANDREW J WIEMER · 2022 to 2026
$1.8M
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases 5-R01-AI150869National Cancer Institute (NCI) 5-R01-CA266138NCI NIH HHS R01 CA266138NIAID NIH HHS R01 AI150869
6 · The paper itself

Abstract

Butyrophilins (BTNs) act as critical sensors of phosphoantigens (pAgs), mediating the immune response to these small molecules. The natural ligands for BTN3A1 include the exogenous (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) and endogenous pAgs dimethyl allyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP), all of which can bind to BTN3A1 followed by activation of γ9δ2 T cells. BTN3A1 shares similar structural domains and exhibits high amino acid sequence homology with BTN3A3. However, the potential functions of BTN3A3 and whether it possesses ligands of its own remain unknown. Here, we show that a single point mutation to BTN3A3 allows it to detect HMBPP, suggesting that the protein may have its own ligand. Mevalonate diphosphate (MPP), a naturally occurring endogenous compound, exhibits high docking scores with both BTN3A1 and BTN3A3. Functional testing revealed that MPP activates γ9δ2 T cells, albeit with a higher EC

Indexed as

ButyrophilinsMevalonic AcidT-LymphocytesAnimalsAntigens, CDCHO CellsCricetulusHemiterpenesHumansLigandsOrganophosphatesOrganophosphorus CompoundsProtein Binding4-hydroxy-3-methyl-2-butenyl diphosphateAntigens, CDBTN3A1 protein, humanButyrophilinsHemiterpenesisopentenyl pyrophosphateLigandsMevalonic AcidOrganophosphatesOrganophosphorus CompoundsB30.2-SPRY domainCancer immunotherapyImmunologyIsoprenoid biosynthesisMolecular glueT cell receptor

Identifiers

PMID41236636
PMCPMC12618762

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.