Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Nicholas J ErnstDepartment of Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0002-6401-3041
Edziu FranczakDepartment of Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0002-0845-4002
Julie AllenDepartment of Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, Kansas, United States.
Everett C MinchewDepartment of Physiology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0003-1196-2865
Andrew T ReadyoffDepartment of Physiology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, United States.
Miles C FarlowDepartment of Physiology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, United States.ORCID 0009-0000-6266-1339
Espen E SpangenburgDepartment of Physiology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0001-8339-1972
Benjamin F MillerAging & Metabolism Research Program; Oklahoma Medical Research Foundation and Oklahoma City Veterans Affairs Medical Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0003-3283-0685
Jill K MorrisDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, United States.
Kartik ShankarUSDA Agricultural Research Service, Responsive Agricultural Food Systems Research Unit, College Station, Texas, United States.
Mihaela E SardiuDepartment of Biostatistics and Data Science, The University of Kansas Medical Center, Kansas City, Kansas, United States.
Hao ZhuDepartment of Clinical Laboratory Sciences, The University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0003-0866-9246
John A StanfordDepartment of Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0002-4667-4057
John P ThyfaultDepartment of Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0001-7920-7466
Colin S McCoinDepartment of Cell Biology and Physiology, The University of Kansas Medical Center, Kansas City, Kansas, United States.ORCID 0000-0002-8557-6441
Funding
Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
University of Kansas Alzheimer's Disease Core CentersP30AG035982 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI BURNS, JEFFREY MURRAY · 2011 to 2020
$16.6M
longitudinal assessment of stress and stress-related concepts across a behavioral weight loss interventionP20GM144269 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John P Thyfault, STEVEN A WEINMAN · 2022 to 2026
$14.9M
Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HOLLY VAN REMMEN · 2015 to 2026
$13.9M
Translating Obesity, Metabolic Dysfunction and Comorbid Disease StatesT32DK128770 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI John P Thyfault, Douglas E Wright · 2022 to 2026
$806k
Metabolic Phenotyping ClusterS10OD028598 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI THYFAULT, JOHN P · 2020 to 2020
$602k
BLRD VA I01 BX002567BLRD VA I01 BX005592HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM103418HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM144269HHS | NIH | NIH Office of the Director (OD) 1S10OD028598Kansas IDeA Network of Biomedical Research Excellence (K-INBRE)KUMC Landon Center on AgingKU | School of Medicine, University of Kansas (KUMC)NCI NIH HHS P30 CA168524NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG050911NIDDK NIH HHS T32 DK128770NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM144269NIH HHS S10 OD028598
6 · The paper itself
Abstract
Reduced muscle mass and function are hallmarks of aging, increased frailty, and reduced resilience. There are no clinically approved interventions besides exercise to improve muscle quality and function in the elderly. We recently found that older participants with mild cognitive impairment (MCI) who took the acetylcholinesterase inhibitor donepezil (DON) had greater skeletal muscle mitochondrial respiratory capacity than nontreated counterparts. Here we tested whether DON treatment or DON + exercise on treadmill (EX) improved muscle and mitochondrial function in male and female mice that were young adult wild type (WT) or with an early aging phenotype [CDGH iron-sulfur domain 2 (Cisd2) knockout mice] (Cisd2KO;
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Donepezil treatment, alone or combined with exercise, enhances skeletal muscle function in healthy and advanced aging disease mouse models. · full record | Socratic