Evidence map›Paper›PMID 41236933›Full record

Trial reportBrain and behavior2025

Basil (Ocimum basilicum) to Alleviate Anxiety in Patients With Major Depressive Disorder: A Randomized Placebo-Controlled Clinical Trial.

Mahva Talaei, Kiarash Zare, Yussef Hashemi, Amir Hesam Pahlevani, Bahareh Fakhraei, Foroogh Namjooyan, Mohammad Hashem Hashempur, Amin Kouhpaye, Sayed Hamdollah Mosavat

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mahva TalaeiStudent Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Kiarash ZareStudent Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Yussef HashemiResearch Center for Psychiatry and Behavior Science, Shiraz University of Medical Sciences, Shiraz, Iran.
Amir Hesam PahlevaniStudent Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Bahareh FakhraeiDepartment of Psychiatry, Shariati Hospital, Fasa University of Medical Sciences, Fasa, Iran.
Foroogh NamjooyanResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Hashem HashempurResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Amin KouhpayeDepartment of Pharmacology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Sayed Hamdollah MosavatResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) is a widespread global mood disorder, often accompanied by anxiety as a common symptom. This study assessed the effectiveness of basil (Ocimum basilicum) syrup in alleviating anxiety in patients with depression.

methodsA randomized single-blinded clinical trial was conducted at Dastgheib Psychiatric Clinic, Fasa University of Medical Sciences. Sixty participants were randomly assigned to receive either basil syrup or a placebo for 4 weeks. Anxiety and depression were assessed using the Hamilton Anxiety Rating Scale (HAM-A) and Beck Depression Inventory (BDI), respectively, before and after the intervention.

resultsThe basil group showed significant reductions in HAM-A and BDI scores compared to the placebo group (p value < 0.05).

conclusionBasil syrup could reduce anxiety in patients with MDD. However, further studies with a larger sample size and longer follow-up period are necessary.

trial registrationIRCT20230318057752N1.

Indexed as

AnxietyMajor Depressive DisorderOcimum basilicumAdultFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSingle-Blind MethodTreatment Outcomeanxietybasildepressionintegrative medicineOcimum basilicumtraditional Persian medicine

Identifiers

PMID41236933
PMCPMC12617443

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.