Evidence map›Paper›PMID 41237242›Full record

ArticleScience advances2025

Structural basis of bacteriophage Ur-lambda infection initiation.

Huaxin Yu, Chunyan Wang, Jian Yue, Wangbiao Guo, Ian J Molineux, Jun Liu

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Review
  3. F-Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. A dramatic protein fold switch powers a bactericidal nanomachine.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huaxin YuDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9375-1916
Chunyan WangDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.
Jian YueDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.
Wangbiao GuoDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5398-4910
Ian J MolineuxLaMontagne Center for Infectious Disease, Institute for Cell and Molecular Biology, Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.ORCID 0000-0003-0184-7652
Jun LiuDepartment of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3108-6735

Funding

Structural basis of phage infection and DNA ejectionR01GM110243 · NIGMS · YALE UNIVERSITY · PI LIU, JUN, MOLINEUX, IAN J · 2014 to 2024
$3.1M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
Initiation of Phage InfectionR01GM124378 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI MOLINEUX, IAN J · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM110243NIGMS NIH HHS R01 GM124378NIH HHS S10 OD023603
6 · The paper itself

Abstract

Bacteriophages must recognize host receptors and penetrate the host cell envelope to initiate infection. How the classic phage λ initiates infection is not yet understood. Here, we combine cryo-electron microscopy and tomography to visualize infection initiation by Ur-λ, the original λ isolate that uses side fibers to adsorb rapidly to

Indexed as

Bacteriophage lambdaCryoelectron MicroscopyEscherichia coliModels, MolecularProtein ConformationViral ProteinsViral Proteins

Identifiers

PMID41237242
PMCPMC12617516

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.