ArticleSmall (Weinheim an der Bergstrasse, Germany)2026
Multifunctional Porous Microshuttles as Scaffolding Components and Carriers of Bioactive Factors in Self-Assembled Microtissues.
Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multifunctional Porous Microshuttles as Scaffolding Components and Carriers of Bioactive Factors in Self-Assembled Microtissues.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Co-assembly of cells and microsized, extracellular matrix (ECM)-mimicking biomaterials, for example, in the form of microparticles, is a promising strategy for generating 3D microtissues. Additionally, microparticles, especially the porous ones, are known for their role as microcarriers in delivery systems, owing to their high specific surface area. Therefore, this work proposes the use of multifunctional, bioactive compound-loaded porous microparticles, or microshuttles, that can simultaneously fulfill the roles of ECM-mimicking scaffolding components and delivery vehicles in self-assembled microtissues. This work presents a one-step emulsification method, followed by a chemical etching step, for generating a library of porous poly(lactic-co-glycolic acid) (PLGA) microparticles with tunable pore sizes. The microparticles undergo cell-guided assembly when co-seeded with human mesenchymal stromal cells (HMSCs) in microwells, forming hybrid cell-biomaterial microtissues. Additionally, the microparticles can be versatile microcarriers of various bone repair-related factors, including bone morphogenetic protein 2 (BMP-2), nanohydroxyapatite (nHA), and human umbilical vein endothelial cells (HUVECs). The results indicate enhanced expression of osteogenic genes and proteins in hybrid microtissues containing BMP-2- and nHA-loaded PLGA microparticles, and improved endothelial network formation in hybrid microtissues containing HUVEC-loaded PLGA microparticles, as compared to HMSC-only microtissues. These findings highlight the potential of the porous PLGA microshuttles in engineering potentially osteogenic, self-assembled microtissues.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.