Evidence map›Paper›PMID 41237893›Full record

ReviewProgress in retinal and eye research2025

Current progress in research on ocular injury caused by exposure to vesicants.

Marina Gorbatyuk, Nishant R Sinha, Rajnish Kumar, Assylbek Zhylkibayev, Mohammad Athar, Patrick McNutt, Rajiv R Mohan

Abstract readReview
In one paragraph

Review in Progress in retinal and eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marina GorbatyukWake Forest University Medical School, Department of Biochemistry, United States. Electronic address: Marina.Gorbatyuk@wfusm.edu.
Nishant R SinhaHarry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States; University of Missouri College of Veterinary Medicine and School of Medicine, Departments of Ophthalmology, United States.
Rajnish KumarHarry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States; University of Missouri College of Veterinary Medicine and School of Medicine, Departments of Ophthalmology, United States.
Assylbek ZhylkibayevWake Forest University Medical School, Department of Biochemistry, United States.
Mohammad AtharUniversity of Alabama at Birmingham School of Medicine, Department of Dermatology, United States.
Patrick McNuttHarry S. Truman Memorial Veterans' Hospital, Columbia, MO, United States; University of Missouri College of Veterinary Medicine and School of Medicine, Departments of Ophthalmology, United States.
Rajiv R MohanWake Forest University Medical School, Institute for Regenerative Medicine, United States; Wake Forest University Medical School, Department of Microbiology and Immunology, United States.

Funding

Wake Forest University Vesicant Exposure Resource and Coordination CoreU2CEY036984 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Patrick Michael McNutt · 2024 to 2026
$4.4M
Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur MustardU01EY031650 · NEI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MOHAN, RAJIV RAVINDRA · 2020 to 2024
$3.7M
Novel approaches for corneal haze/fibrosis eliminationR01EY030774 · NEI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MOHAN, RAJIV RAVINDRA · 2019 to 2022
$1.5M
The mechanism of vesicant-induced ocular injuryR01EY034110 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GORBATYUK, MARINA · 2022 to 2024
$1.5M
Toxic Mechanisms of Vesicating Chemicals in the EyeR01EY034139 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNUTT, PATRICK MICHAEL · 2022 to 2024
$1.4M
BLRD VA I01 BX000357BLRD VA IK6 BX005646NEI NIH HHS R01 EY030774NEI NIH HHS R01 EY034110NEI NIH HHS R01 EY034139NEI NIH HHS U01 EY031650NEI NIH HHS U2C EY036984
6 · The paper itself

Abstract

Vesicants, powerful chemical weapons of mass destruction, are agents that cause blistering of the skin and blindness upon accidental exposure or during warfare. In addition, their exposure induces a wide range of other symptoms, including those affecting the respiratory tract, digestive system, skin, and ocular tissues. The ocular tissue can be exposed through both direct and indirect routes, such as direct contact with the affected corneal tissue and systemic blood circulation. Investigating eye injuries caused by vesicants is a critical and growing field of research in ophthalmology and ocular toxicology. In this review, we present the current status of the research, covering significant advances made in the study of vesicant-induced corneal and retinal injuries. We also provide general information on vesicants and discuss animal models used to investigate the molecular mechanisms of vesicant exposure and to develop medical countermeasures. Finally, we identify gaps in the current knowledge of the molecular mechanisms of vesicant action and highlight future directions for this emerging field.

Indexed as

Chemical Warfare AgentsCorneal InjuriesEye InjuriesIrritantsAnimalsDisease Models, AnimalHumansChemical Warfare AgentsIrritants

Identifiers

PMID41237893
PMCPMC12724435

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.