Trial reportThe Journal of nutrition2026
Dose-Response Effects of Cottonseed Oil on Blood Lipid Responses in Adults at Risk of Cardiovascular Disease: A Randomized Controlled Trial.
Trial report in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05686954 (Nutritional Effects of Different Doses of Cottonseed Oil in Humans), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutritional Effects of Different Doses of Cottonseed Oil in Humans
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCottonseed oil (CSO) has displayed beneficial effects regarding blood lipids, albeit in relatively high doses.
objectivesThe aim was to examine the effects of 3 doses of CSO compared with a control (CON) diet on blood lipids in adults at risk of cardiovascular disease (CVD).
methodsNinety-one adults with obesity and/or hypercholesterolemia completed this randomized, parallel clinical trial with a 4-wk partial outpatient feeding intervention. Participants were randomly assigned into 1 of 4 groups: intervention group received 10% estimated energy needs (EEN) from cottonseed oil (LOW) (n = 23), intervention group received 20% EEN from cottonseed oil (MID) (n = 23), or intervention group received 30% EEN from cottonseed oil (HIGH) (n = 22) providing 10%, 20%, or 30% of EEN from CSO, respectively, or control (CON) (n = 23), receiving 10% of EEN from a combination of oils. Fasting blood lipids were obtained at preintervention and postintervention visits, followed by a high-fat meal challenge (35% EEN) with 5-h postprandial blood draws to evaluate lipid metabolism.
resultsCompared with the control diet, total cholesterol decreased in LOW, MID, and HIGH, respectively (-10.2 mg/dL; -12.5 mg/dL; -13.9 mg/dL, respectively; P < 0.05 for all). Similarly, non-high-density lipoprotein cholesterol decreased in LOW, MID, and HIGH (-10.2 mg/dL; -15.8 mg/dL; -16.5, respectively; P < 0.05 for all) compared with CON. Low-density lipoprotein cholesterol reduced in MID and HIGH (-11.7 mg/dL and -12.9 mg/dL, respectively; P < 0.05 for both) with a trend for reduction in LOW (-6.8 mg/dL; P = 0.08) compared with no change in CON. Postprandial triglycerides were reduced in HIGH (-14.7 mg/dL, P = 0.02) compared with LOW, MID, and CON.
conclusionsEnriching diets with 10%, 20%, and 30% CSO improved fasting blood lipids in CVD at-risk adults, with the best results in the 20% and 30% doses. This trial was registered at clinicaltrials.gov as NCT05686954.
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